7PGL

HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form

Summary for 7PGL

• Entry DOI: 10.2210/pdb7pgl/pdb
• Descriptor: Hedgehog-interacting protein (1 entity in total)
• Functional Keywords: hhip, hedgehog, morphogen, signalling, glycosaminoglycan, cholesterol, palmitate, secreted, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 21085.14

Authors

Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinuskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. (deposition date: 2021-08-14, release date: 2021-12-15, Last modification date: 2021-12-22)

• Primary citation: Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinauskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C.; Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.; Nat Commun, 12:7171-7171, 2021; PubMed: 34887403; DOI: 10.1038/s41467-021-27475-2

Experimental method

X-RAY DIFFRACTION (2.63 Å)