6RTW

Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate

Summary for 6RTW

Entry DOI	10.2210/pdb6rtw/pdb
Descriptor	Protein patched homolog 1, Llama-derived nanobody NB64, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	---- hedgehog morphogen receptor, receptor-nanobody complex, cholesterol, palmitate, lipid-protein-modification, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	49332.67
Authors	Rudolf, A.F.,Kowatsch, C.,El Omari, K.,Malinauskas, T.,Kinnebrew, M.,Ansell, T.B.,Bishop, B.,Pardon, E.,Schwab, R.A.,Qian, M.,Duman, R.,Covey, D.F.,Steyaert, J.,Wagner, A.,Sansom, M.S.P.,Rohatgi, R.,Siebold, C. (deposition date: 2019-05-27, release date: 2019-10-02, Last modification date: 2024-01-24)
Primary citation	Rudolf, A.F.,Kinnebrew, M.,Kowatsch, C.,Ansell, T.B.,El Omari, K.,Bishop, B.,Pardon, E.,Schwab, R.A.,Malinauskas, T.,Qian, M.,Duman, R.,Covey, D.F.,Steyaert, J.,Wagner, A.,Sansom, M.S.P.,Rohatgi, R.,Siebold, C. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15:975-982, 2019 Cited by PubMed: 31548691 DOI: 10.1038/s41589-019-0370-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation