3KQ6
 
 | | Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. | | 登録日 | 2009-11-17 | | 公開日 | 2010-02-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
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3V1G
 | | Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | | 登録日 | 2011-12-09 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health
To be Published
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3V19
 | | Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | | 登録日 | 2011-12-09 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health
To be Published
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6X8M
 | | CryoEM structure of the holo-SrpI encapsulin complex from Synechococcus elongatus PCC 7942 | | 分子名称: | Protein SrpI | | 著者 | LaFrance, B.J, Nichols, R.J, Phillips, N.R, Oltrogge, L.M, Valentin-Alvarado, L.E, Bischoff, A.J, Savage, D.F, Nogales, E. | | 登録日 | 2020-06-01 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism.
Elife, 10, 2021
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6X8T
 | | CryoEM structure of the apo-SrpI encapasulin complex from Synechococcus elongatus PCC 7942 | | 分子名称: | Protein SrpI | | 著者 | LaFrance, B.J, Nichols, R.J, Phillips, N.R, Oltrogge, L.M, Valentin-Alvarado, L.E, Bischoff, A.J, Savage, D.F, Nogales, E. | | 登録日 | 2020-06-01 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism.
Elife, 10, 2021
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4IUZ
 | | High resolution crystal structure of racemic ester insulin | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ... | | 著者 | Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H. | | 登録日 | 2013-01-22 | | 公開日 | 2013-02-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135, 2013
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3FQ9
 | | Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | | 分子名称: | Insulin, ZINC ION | | 著者 | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | | 登録日 | 2009-01-07 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
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1LPV
 | | DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES | | 分子名称: | Doublesex protein, ZINC ION | | 著者 | Zhu, L, Wilken, J, Phillips, N, Narendra, U, Chan, G, Stratton, S, Kent, S, Weiss, M.A. | | 登録日 | 2002-05-08 | | 公開日 | 2002-10-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.
Genes Dev., 14, 2000
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1KLS
 | | NMR Structure of the ZFY-6T[Y10L] Zinc Finger | | 分子名称: | ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION | | 著者 | Lachenmann, M.J, Ladbury, J.E, Phillips, N.B, Narayana, N, Qian, X, Weiss, M.A. | | 登録日 | 2001-12-12 | | 公開日 | 2002-03-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
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1KLR
 | | NMR Structure of the ZFY-6T[Y10F] Zinc Finger | | 分子名称: | ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION | | 著者 | Lachenmann, M.J, Ladbury, J.E, Phillips, N.B, Narayana, N, Qian, X, Weiss, M.A. | | 登録日 | 2001-12-12 | | 公開日 | 2002-03-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
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2GYP
 | | Diabetes mellitus due to a frustrated Schellman motif in HNF-1a | | 分子名称: | Hepatocyte nuclear factor 1-alpha | | 著者 | Narayana, N, Phillips, N.B, Hua, Q.X, Jia, W, Weiss, M.A. | | 登録日 | 2006-05-09 | | 公開日 | 2007-03-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha.
J.Mol.Biol., 362, 2006
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1ZV1
 | | Crystal structure of the dimerization domain of doublesex protein from D. melanogaster | | 分子名称: | Doublesex protein | | 著者 | Weiss, M.A, Bayrer, J.R, Wan, Z, Li, B, Phillips, N.B. | | 登録日 | 2005-06-01 | | 公開日 | 2005-08-09 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation
J.Biol.Chem., 280, 2005
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3P2X
 | | Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2010-10-04 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
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3P33
 | | Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2010-10-04 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
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