1COL
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![BU of 1col by Molmil](/molmil-images/mine/1col) | REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION | Descriptor: | COLICIN A | Authors: | Parker, M.W, Postma, J.P.M, Pattus, F, Tucker, A.D, Tsernoglou, D. | Deposit date: | 1991-07-06 | Release date: | 1992-07-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Refined structure of the pore-forming domain of colicin A at 2.4 A resolution. J.Mol.Biol., 224, 1992
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1PRE
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![BU of 1pre by Molmil](/molmil-images/mine/1pre) | PROAEROLYSIN | Descriptor: | PROAEROLYSIN | Authors: | Parker, M.W, Buckley, J.T, Postma, J.P.M, Tucker, A.D, Tsernoglou, D. | Deposit date: | 1995-09-15 | Release date: | 1996-10-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states. Nature, 367, 1994
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4ZGH
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![BU of 4zgh by Molmil](/molmil-images/mine/4zgh) | Structure of Sugar Binding Protein Pneumolysin | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GOLD (I) CYANIDE ION, ... | Authors: | Parker, M.W, Feil, S.C, Morton, C. | Deposit date: | 2015-04-23 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation. Sci Rep, 5, 2015
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1Z52
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![BU of 1z52 by Molmil](/molmil-images/mine/1z52) | Proaerolysin Mutant W373L | Descriptor: | Aerolysin | Authors: | Parker, M.W, Feil, S.C, Tang, J.W. | Deposit date: | 2005-03-16 | Release date: | 2006-03-07 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal Structure of Proaerolysin at 2.3 A Resolution and Structural Analyses of Single-site Mutants as a Basis for Understanding Membrane Insertion of the Toxin To be Published
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5DIM
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![BU of 5dim by Molmil](/molmil-images/mine/5dim) | |
5DHL
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![BU of 5dhl by Molmil](/molmil-images/mine/5dhl) | |
4QDQ
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![BU of 4qdq by Molmil](/molmil-images/mine/4qdq) | Physical basis for Nrp2 ligand binding | Descriptor: | GLYCEROL, Neuropilin-2, SULFATE ION | Authors: | Parker, M.W, Vander Kooi, C.W. | Deposit date: | 2014-05-14 | Release date: | 2015-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form. Structure, 23, 2015
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4QDR
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![BU of 4qdr by Molmil](/molmil-images/mine/4qdr) | |
4QDS
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![BU of 4qds by Molmil](/molmil-images/mine/4qds) | Physical basis for Nrp2 ligand binding | Descriptor: | ACETATE ION, GLYCEROL, Neuropilin-2 | Authors: | Parker, M.W, Vander Kooi, C.W. | Deposit date: | 2014-05-14 | Release date: | 2015-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form. Structure, 23, 2015
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4NKQ
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![BU of 4nkq by Molmil](/molmil-images/mine/4nkq) | Structure of a Cytokine Receptor Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, ... | Authors: | Parker, M.W, Broughton, S.E. | Deposit date: | 2013-11-13 | Release date: | 2015-09-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling. Structure, 24, 2016
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4FHA
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![BU of 4fha by Molmil](/molmil-images/mine/4fha) | Structure of Dihydrodipicolinate Synthase from Streptococcus pneumoniae,bound to pyruvate and lysine | Descriptor: | Dihydrodipicolinate synthase, LYSINE, SODIUM ION | Authors: | Perugini, M.A, Dogovski, C, Parker, M.W, Gorman, M.A. | Deposit date: | 2012-06-06 | Release date: | 2013-09-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structure, Function, Stability and Knockout Phenotype of Dihydrodipicolinate Synthase from Streptococcus pneumoniae To be Published
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2LJR
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![BU of 2ljr by Molmil](/molmil-images/mine/2ljr) | GLUTATHIONE TRANSFERASE APO-FORM FROM HUMAN | Descriptor: | GLUTATHIONE S-TRANSFERASE | Authors: | Rossjohn, J, Mckinstry, W.J, Oakley, A.J, Verger, D, Flanagan, J, Chelvanayagam, G, Tan, K.L, Board, P.G, Parker, M.W. | Deposit date: | 1998-03-08 | Release date: | 1999-03-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. Structure, 6, 1998
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6D48
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![BU of 6d48 by Molmil](/molmil-images/mine/6d48) | Cell Surface Receptor | Descriptor: | Myeloid cell surface antigen CD33 | Authors: | Hermans, S.J, Miles, L.A, Parker, M.W. | Deposit date: | 2018-04-17 | Release date: | 2019-04-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.776 Å) | Cite: | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19, 2019
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6D49
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![BU of 6d49 by Molmil](/molmil-images/mine/6d49) | Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution | Descriptor: | 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, GLYCEROL, Myeloid cell surface antigen CD33 | Authors: | Hermans, S.J, Miles, L.A, Parker, M.W. | Deposit date: | 2018-04-17 | Release date: | 2019-04-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19, 2019
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6D4A
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![BU of 6d4a by Molmil](/molmil-images/mine/6d4a) | Cell Surface Receptor with Bound Ligand at 1.75-A Resolution | Descriptor: | 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, GLYCEROL, Myeloid cell surface antigen CD33 | Authors: | Hermans, S.J, Miles, L.A, Parker, M.W. | Deposit date: | 2018-04-17 | Release date: | 2019-04-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19, 2019
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6WC8
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![BU of 6wc8 by Molmil](/molmil-images/mine/6wc8) | |
6WE7
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![BU of 6we7 by Molmil](/molmil-images/mine/6we7) | |
6WM8
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![BU of 6wm8 by Molmil](/molmil-images/mine/6wm8) | |
5VP3
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![BU of 5vp3 by Molmil](/molmil-images/mine/5vp3) | Light-sensitive photoprotein | Descriptor: | CADMIUM ION, Mnemiopsin 1, NICKEL (II) ION, ... | Authors: | Gorman, M.A, Parker, M.W. | Deposit date: | 2017-05-04 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations. J. Biol. Chem., 294, 2019
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1MD4
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![BU of 1md4 by Molmil](/molmil-images/mine/1md4) | A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase | Authors: | Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W. | Deposit date: | 2002-08-06 | Release date: | 2002-08-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1 J.Biol.Chem., 278, 2003
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4OJF
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![BU of 4ojf by Molmil](/molmil-images/mine/4ojf) | Humanised 3D6 Fab complexed to amyloid beta 1-8 | Descriptor: | Amyloid beta A4 protein, Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain | Authors: | Miles, L.A, Crespi, G.A.N, Parker, M.W. | Deposit date: | 2014-01-21 | Release date: | 2015-01-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta ACTA CRYSTALLOGR.,SECT.F, 70, 2014
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7RQ0
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4OGB
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![BU of 4ogb by Molmil](/molmil-images/mine/4ogb) | Crystal structure of the catalytic domain of PDE4D2 with compound 2 | Descriptor: | (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Feil, S.C, Parker, M.W. | Deposit date: | 2014-01-15 | Release date: | 2015-01-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.032 Å) | Cite: | The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors To be Published
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3N9J
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6XD4
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![BU of 6xd4 by Molmil](/molmil-images/mine/6xd4) | CDC-like protein | Descriptor: | ACETATE ION, Hemolysin, SODIUM ION | Authors: | Morton, C.J, Parker, M.W, Lawrence, S.L, Johnstone, B.A, Tweten, R.K. | Deposit date: | 2020-06-09 | Release date: | 2021-04-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins. Mbio, 11, 2020
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