4OGB

Crystal structure of the catalytic domain of PDE4D2 with compound 2

Summary for 4OGB

• Entry DOI: 10.2210/pdb4ogb/pdb
• Related: 1PTW 3SL3 3SL4 3SL5 3SL6 3SL8
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol, 1,2-ETHANEDIOL, ... (8 entities in total)
• Functional Keywords: catalytic mechanism, camp hydrolysis, hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Apical cell membrane : Q08499
• Total number of polymer chains: 4
• Total formula weight: 171266.38

Authors

Feil, S.C.,Parker, M.W. (deposition date: 2014-01-15, release date: 2015-01-21, Last modification date: 2024-02-28)

• Primary citation: Howard, B.L.,Nankervis, J.L.,Feil, S.C.,Manallack, D.T.,Holien, J.K.,Zhen, Z.,Jennings, I.G.,Abbott, B.M.,Parker, M.W.,Thompson, P.E.; The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.032 Å)