4OGB
Crystal structure of the catalytic domain of PDE4D2 with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 361 | 41523.9 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (human) | DPDE3, PDE43 |
| 2 | E, FA, S, SA (A, C, B, D) | (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol | non-polymer | 382.4 | 4 | Chemie (2SR) | |||
| 3 | AA, AB, BB, CA, EA... (B, D, C, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 32 | Chemie (EDO) | |||
| 4 | FB, GB, H, XA (D, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 5 | CB, DB, M, N, NA... (D, A, C, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 6 | BA, DA, O, Q, UA... (B, A, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
| 7 | JA (C) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 8 | HB, IB, JB, KB (A, B, C, D) | water | water | 18.0 | 432 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 166095.5 | |
| Non-Polymers* | Number of molecules | 55 |
| Total formula weight | 5170.8 | |
| All* | Total formula weight | 171266.4 |
