7RQ0

HIV Integrase CORE domain in complex with 2-{2-[2-(3-{[4-(2-{[(3-{2-[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}phenyl)methyl]amino}ethyl)piperazin-1-yl]methyl}phenyl)ethynyl]-5-methyl-1-benzofuran-3-yl}acetic acid

Summary for 7RQ0

• Entry DOI: 10.2210/pdb7rq0/pdb
• Related: 6WE7
• Descriptor: Integrase, SULFATE ION, IODIDE ION, ... (5 entities in total)
• Functional Keywords: hiv, integrase, inhibitor complex, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 37627.33

Authors

Gorman, M.A.,Parker, M.W. (deposition date: 2021-08-05, release date: 2022-08-10, Last modification date: 2023-10-18)

• Primary citation: Gorman, M.A.,Parker, M.W.; HIV integrase-LEDGF interaction screening by fragment linking using off-rate screening; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)