7XYZ
 
 | | TRIM E3 ubiquitin ligase | | Descriptor: | Tripartite motif-containing protein 72, ZINC ION | | Authors: | Park, S.H, Song, H.K. | | Deposit date: | 2022-06-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (4.62 Å) | | Cite: | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Nat.Struct.Mol.Biol., 30, 2023
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7XZ2
 | | TRIM E3 ubiquitin ligase | | Descriptor: | Tripartite motif-containing protein 72, ZINC ION | | Authors: | Park, S.H, Song, H.K. | | Deposit date: | 2022-06-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Nat.Struct.Mol.Biol., 30, 2023
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7XYY
 | | TRIM E3 ubiquitin ligase WT | | Descriptor: | Tripartite motif-containing protein 72, ZINC ION | | Authors: | Park, S.H, Song, H.K. | | Deposit date: | 2022-06-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (7.1 Å) | | Cite: | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Nat.Struct.Mol.Biol., 30, 2023
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7XZ1
 | | TRIM E3 ubiquitin ligase | | Descriptor: | Tripartite motif-containing protein 72, ZINC ION | | Authors: | Park, S.H, Song, H.K. | | Deposit date: | 2022-06-02 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (5.2 Å) | | Cite: | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
Nat.Struct.Mol.Biol., 30, 2023
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2ROM
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6W5I
 | | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) | | Descriptor: | DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | | Deposit date: | 2020-03-13 | | Release date: | 2021-03-31 | | Last modified: | 2022-10-12 | | Method: | ELECTRON MICROSCOPY (6.9 Å) | | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.
Nat Commun, 12, 2021
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6W5N
 | | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) | | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | | Deposit date: | 2020-03-13 | | Release date: | 2021-03-31 | | Last modified: | 2022-10-12 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.
Nat Commun, 12, 2021
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6W5M
 | | Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) | | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | | Deposit date: | 2020-03-13 | | Release date: | 2021-03-31 | | Last modified: | 2022-10-12 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.
Nat Commun, 12, 2021
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7SFZ
 | | Crystal structure of Mis18a-yippee domain | | Descriptor: | Protein Mis18-alpha, SULFATE ION, ZINC ION | | Authors: | Park, S.H, Cho, U. | | Deposit date: | 2021-10-04 | | Release date: | 2022-10-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.002 Å) | | Cite: | Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance
To Be Published
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7MBN
 | | Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02 | | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | | Deposit date: | 2021-04-01 | | Release date: | 2021-12-29 | | Last modified: | 2022-01-19 | | Method: | ELECTRON MICROSCOPY | | Cite: | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
Biochemistry, 61, 2022
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7MBM
 | | Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01 | | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | | Deposit date: | 2021-04-01 | | Release date: | 2021-12-29 | | Last modified: | 2022-01-19 | | Method: | ELECTRON MICROSCOPY | | Cite: | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
Biochemistry, 61, 2022
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6JLD
 | | Crystal structure of a human ependymin related protein | | Descriptor: | Mammalian ependymin-related protein 1 | | Authors: | Park, S.Y. | | Deposit date: | 2019-03-05 | | Release date: | 2019-07-10 | | Last modified: | 2019-07-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder.
Iucrj, 6, 2019
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6JL9
 | | Crystal structure of a frog ependymin related protein | | Descriptor: | CALCIUM ION, Ependymin-related 1 | | Authors: | Park, S.Y. | | Deposit date: | 2019-03-04 | | Release date: | 2019-07-10 | | Last modified: | 2019-07-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder.
Iucrj, 6, 2019
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3H1T
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5FGM
 | | Streptomyces coelicolor SigR region 4 | | Descriptor: | ECF RNA polymerase sigma factor SigR | | Authors: | Park, S.Y. | | Deposit date: | 2015-12-21 | | Release date: | 2016-03-02 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | In Streptomyces coelicolor SigR, methionine at the -35 element interacting region 4 confers the -31'-adenine base selectivity
Biochem.Biophys.Res.Commun., 470, 2016
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6AGQ
 | | Acetyl xylan esterase from Paenibacillus sp. R4 | | Descriptor: | ZINC ION, acetyl xylan esterase | | Authors: | Park, S, Lee, C.W, Lee, J.H. | | Deposit date: | 2018-08-13 | | Release date: | 2018-10-10 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure and functional characterization of a cold-active acetyl xylan esterase (PbAcE) from psychrophilic soil microbe Paenibacillus sp.
PLoS ONE, 13, 2018
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7SFY
 | | Crystal structure of human Mis18ab_cc | | Descriptor: | Protein Mis18-alpha, Protein Mis18-beta | | Authors: | Park, S.H, Cho, U. | | Deposit date: | 2021-10-04 | | Release date: | 2023-04-12 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance
To Be Published
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5EEP
 | | Crystal structure of E. coli CsdE | | Descriptor: | CsdA-binding activator | | Authors: | Park, S.Y. | | Deposit date: | 2015-10-23 | | Release date: | 2016-06-08 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The crystal structure of Escherichia coli CsdE
Int.J.Biol.Macromol., 87, 2016
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5U7G
 | | Crystal Structure of the Catalytic Core of CBP | | Descriptor: | CREB-binding protein, ZINC ION | | Authors: | Park, S, Stanfield, R.L, Martinez-Yamout, M.M, Dyson, H.J, Wilson, I.A, Wright, P.E. | | Deposit date: | 2016-12-12 | | Release date: | 2017-06-21 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4N7Z
 | | Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep192 N-terminal fragment | | Descriptor: | Centrosomal protein of 192 kDa, Serine/threonine-protein kinase PLK4 | | Authors: | Park, S.-Y, Park, J.-E, Tian, L, Kim, T.-S, Yang, W, Lee, K.S. | | Deposit date: | 2013-10-16 | | Release date: | 2014-07-02 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
Nat.Struct.Mol.Biol., 21, 2014
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6JLA
 | | Crystal structure of a mouse ependymin related protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Mammalian ependymin-related protein 1 | | Authors: | Park, S. | | Deposit date: | 2019-03-04 | | Release date: | 2020-03-04 | | Last modified: | 2020-09-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder.
Iucrj, 6, 2019
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4N7V
 | | Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment | | Descriptor: | Centrosomal protein of 152 kDa, Serine/threonine-protein kinase PLK4 | | Authors: | Park, S.-Y, Park, J.-E, Tian, L, Kim, T.-S, Yang, W, Lee, K.S. | | Deposit date: | 2013-10-16 | | Release date: | 2014-07-02 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.758 Å) | | Cite: | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
Nat.Struct.Mol.Biol., 21, 2014
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4FVC
 | | HmoB structure with heme | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Putative uncharacterized protein yhgC | | Authors: | Park, S. | | Deposit date: | 2012-06-29 | | Release date: | 2013-07-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of HmoB with Heme
To be Published
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5I0B
 | | Structure of PAK4 | | Descriptor: | 6-bromo-2-[1-methyl-3-(propan-2-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridine, Serine/threonine-protein kinase PAK 4 | | Authors: | Park, S.Y. | | Deposit date: | 2016-02-03 | | Release date: | 2016-12-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor
Bioorg. Med. Chem. Lett., 26, 2016
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6L18
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