4N7Z
Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep192 N-terminal fragment
Summary for 4N7Z
Entry DOI | 10.2210/pdb4n7z/pdb |
Related | 4N7V |
Descriptor | Serine/threonine-protein kinase PLK4, Centrosomal protein of 192 kDa (3 entities in total) |
Functional Keywords | k/r crater, d-rich motif, centriole biogenesis, cep192, centrosome, cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: O00444 |
Total number of polymer chains | 2 |
Total formula weight | 33242.58 |
Authors | Park, S.-Y.,Park, J.-E.,Tian, L.,Kim, T.-S.,Yang, W.,Lee, K.S. (deposition date: 2013-10-16, release date: 2014-07-02, Last modification date: 2023-09-20) |
Primary citation | Park, S.Y.,Park, J.E.,Kim, T.S.,Kim, J.H.,Kwak, M.J.,Ku, B.,Tian, L.,Murugan, R.N.,Ahn, M.,Komiya, S.,Hojo, H.,Kim, N.H.,Kim, B.Y.,Bang, J.K.,Erikson, R.L.,Lee, K.W.,Kim, S.J.,Oh, B.H.,Yang, W.,Lee, K.S. Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat.Struct.Mol.Biol., 21:696-703, 2014 Cited by PubMed: 24997597DOI: 10.1038/nsmb.2846 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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