9BIS
 
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to amoxicillin | | Descriptor: | 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-04-24 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
To Be Published
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9BIT
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1 | | Descriptor: | CLOXACILLIN, Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-04-24 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
To Be Published
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9BIR
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cefadroxil | | Descriptor: | Cefadroxil, Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-04-24 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
To Be Published
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9BIU
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 2 | | Descriptor: | CLOXACILLIN, Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-04-24 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
To Be Published
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8APY
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5UFE
 | | Wild-type K-Ras(GNP)/R11.1.6 complex | | Descriptor: | CADMIUM ION, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Parker, J.A, Mattos, C. | | Deposit date: | 2017-01-04 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | An engineered protein antagonist of K-Ras/B-Raf interaction.
Sci Rep, 7, 2017
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5UFQ
 | | K-RasG12D(GNP)/R11.1.6 complex | | Descriptor: | CADMIUM ION, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Parker, J.A, Mattos, C. | | Deposit date: | 2017-01-05 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.199 Å) | | Cite: | An engineered protein antagonist of K-Ras/B-Raf interaction.
Sci Rep, 7, 2017
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8BVS
 | | Cryo-EM structure of rat SLC22A6 bound to tenofovir | | Descriptor: | CHLORIDE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody), ... | | Authors: | Parker, J.L, Kato, T, Newstead, S. | | Deposit date: | 2022-12-05 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.61 Å) | | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
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8BVR
 | | Cryo-EM structure of rat SLC22A6 in the apo state | | Descriptor: | PHOSPHATE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) | | Authors: | Parker, J.L, Kato, T, Newstead, S. | | Deposit date: | 2022-12-05 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
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8BVT
 | | Cryo-EM structure of rat SLC22A6 bound to probenecid | | Descriptor: | 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) | | Authors: | Parker, J.L, Kato, T, Newstead, S. | | Deposit date: | 2022-12-06 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
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8BW7
 | | Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid | | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ... | | Authors: | Parker, J.L, Kato, T, Newstead, S. | | Deposit date: | 2022-12-06 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
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1W9H
 | | The Structure of a Piwi protein from Archaeoglobus fulgidus. | | Descriptor: | CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ... | | Authors: | Parker, J.S, Roe, S.M, Barford, D. | | Deposit date: | 2004-10-13 | | Release date: | 2005-01-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
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2W42
 | | THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX. | | Descriptor: | 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ... | | Authors: | Parker, J.S, Roe, S.M, Barford, D. | | Deposit date: | 2008-11-19 | | Release date: | 2008-12-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
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5UK9
 | | Wild-type K-Ras(GCP) pH 6.5 | | Descriptor: | GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Parker, J.A, Mattos, C. | | Deposit date: | 2017-01-20 | | Release date: | 2018-01-10 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.887 Å) | | Cite: | K-Ras Populates Conformational States Differently from Its Isoform H-Ras and Oncogenic Mutant K-RasG12D.
Structure, 26, 2018
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2BGG
 | | The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA duplex. | | Descriptor: | 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ... | | Authors: | Parker, J.S, Roe, S.M, Barford, D. | | Deposit date: | 2004-12-22 | | Release date: | 2005-03-31 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
Nature, 434, 2005
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5A2N
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5A2O
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7YXA
 | | XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... | | Authors: | Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | | Deposit date: | 2022-02-15 | | Release date: | 2022-08-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors.
Nat Commun, 13, 2022
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4G4W
 | | Crystal structure of peptidoglycan-associated lipoprotein from Acinetobacter baumannii | | Descriptor: | ALANINE, GLYCEROL, Peptidoglycan-associated lipoprotein, ... | | Authors: | Lee, W.C, Song, J.H, Park, J.S, Kim, H.Y. | | Deposit date: | 2012-07-16 | | Release date: | 2013-07-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Enantiomer-dependent amino acid binding affinity of OmpA-like domains from Acinetobacter baumannii peptidoglycan-associated lipoprotein and OmpA
to be published
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7CLT
 | | Crystal structure of the EFhd1/Swiprosin-2, a mitochondrial actin-binding protein | | Descriptor: | CALCIUM ION, EF-hand domain-containing protein D1, GLYCEROL, ... | | Authors: | Mun, S.A, Park, J, Park, K.R, Lee, Y, Kang, J.Y, Park, T, Jin, M, Yang, J, Jun, C.D, Eom, S.H. | | Deposit date: | 2020-07-22 | | Release date: | 2021-01-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.07380986 Å) | | Cite: | Structural and Biochemical Characterization of EFhd1/Swiprosin-2, an Actin-Binding Protein in Mitochondria.
Front Cell Dev Biol, 8, 2020
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7C4P
 | | Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA | | Descriptor: | DNA (5'-D(*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), ... | | Authors: | Jin, Z, Park, J.H, Yun, J.H, Park, S.Y, Lee, W. | | Deposit date: | 2020-05-18 | | Release date: | 2021-05-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.995 Å) | | Cite: | Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA
To Be Published
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7C4Q
 | | Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA | | Descriptor: | DNA (5'-D(*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), ... | | Authors: | Jin, Z, Park, J.H, Yun, J.H, Park, S.Y, Lee, W. | | Deposit date: | 2020-05-18 | | Release date: | 2021-05-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA
To Be Published
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7C4R
 | | Crystal structure of hydrogen peroxide treated zebrafish TRF2 complexed with DNA | | Descriptor: | DNA (5'-D(*D*CP*DP*CP*DP*CP*DP*TP*DP*AP*DP*AP*DP*CP*DP*CP*DP*CP*DP*TP*DP*AP*DP*A)-3'), DNA (5'-D(*D*TP*DP*TP*DP*AP*DP*GP*DP*GP*DP*GP*DP*TP*DP*TP*DP*AP*DP*G)-3'), DNA (5'-D(*D*TP*DP*TP*DP*AP*DP*GP*DP*GP*DP*GP*DP*TP*DP*TP*DP*AP*DP*GP*DP*GP*DP*G)-3'), ... | | Authors: | Jin, Z, Park, J.H, Yun, J.H, Park, S.Y, Lee, W. | | Deposit date: | 2020-05-18 | | Release date: | 2021-05-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Crystal structure of hydrogen peroxide treated zebrafish TRF2 myb-domain complexed with DNA
To Be Published
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8GOB
 | | Crystal Structure of Glycerol Dehydrogenase in the presence of NAD+ | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycerol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Park, T, Hoang, H.N, Kang, J.Y, Park, J, Mun, S.A, Jin, M, Yang, J, Jung, C.-H, Eom, S.H. | | Deposit date: | 2022-08-24 | | Release date: | 2023-06-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and functional insights into the flexible beta-hairpin of glycerol dehydrogenase.
Febs J., 290, 2023
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8GOA
 | | Crystal Structure of Glycerol Dehydrogenase in the absence of NAD+ | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycerol dehydrogenase, ZINC ION | | Authors: | Park, T, Hoang, H.N, Kang, J.Y, Park, J, Mun, S.A, Jin, M, Yang, J, Jung, C.-H, Eom, S.H. | | Deposit date: | 2022-08-24 | | Release date: | 2023-06-14 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural and functional insights into the flexible beta-hairpin of glycerol dehydrogenase.
Febs J., 290, 2023
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