9BIS

Cryo-EM structure of the mammalian peptide transporter PepT2 bound to amoxicillin

Summary for 9BIS

• Entry DOI: 10.2210/pdb9bis/pdb
• EMDB information: 44600
• Descriptor: Solute carrier family 15 member 2, nanobody, 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: protein-coupled peptide transporter, peptide transport, antibiotics, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 97339.37

Authors

Parker, J.L.,Deme, J.C.,Lea, S.M.,Newstead, S. (deposition date: 2024-04-24, release date: 2024-07-24)

• Primary citation: Parker, J.L.,Deme, J.C.,Lichtinger, S.M.,Kuteyi, G.,Biggin, P.C.,Lea, S.M.,Newstead, S.; Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)