8BVS

Cryo-EM structure of rat SLC22A6 bound to tenofovir

Summary for 8BVS

• Entry DOI: 10.2210/pdb8bvs/pdb
• EMDB information: 16270
• Descriptor: Solute carrier family 22 member 6, Synthetic nanobody (Sybody), [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYLPHOSPHONIC ACID, ... (4 entities in total)
• Functional Keywords: membrane protein, transporter
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 76956.04

Authors

Parker, J.L.,Kato, T.,Newstead, S. (deposition date: 2022-12-05, release date: 2023-07-19, Last modification date: 2023-11-22)

• Primary citation: Parker, J.L.,Kato, T.,Kuteyi, G.,Sitsel, O.,Newstead, S.; Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.; Nat.Struct.Mol.Biol., 30:1786-1793, 2023; PubMed: 37482561; DOI: 10.1038/s41594-023-01039-y

Experimental method

ELECTRON MICROSCOPY (3.61 Å)