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PDB: 434 results

6OSH
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BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.117 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
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BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.083 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
3SV0
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BU of 3sv0 by Molmil
Crystal structure of casein kinase-1 like protein in plant
Descriptor: Casein kinase I-like
Authors:Park, H.H, Do, K.H.
Deposit date:2011-07-12
Release date:2012-06-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional studies of casein kinase I-like protein from rice
Plant Cell.Physiol., 53, 2012
4W4X
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BU of 4w4x by Molmil
JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Descriptor: 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
Authors:Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
8Z9B
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BU of 8z9b by Molmil
Low molecular weight antigen MTB12
Descriptor: Low molecular weight antigen MTB12
Authors:Park, H.H, Han, J.H.
Deposit date:2024-04-23
Release date:2024-05-29
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Novel structure of secreted small molecular weight antigen Mtb12 from Mycobacterium tuberculosis.
Biochem.Biophys.Res.Commun., 717, 2024
4Y5H
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BU of 4y5h by Molmil
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
Descriptor: 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea, Mitogen-activated protein kinase 10
Authors:Park, H.
Deposit date:2015-02-11
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.055 Å)
Cite:Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
5XPC
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BU of 5xpc by Molmil
Crystal Structure of Drep4 CIDE domain
Descriptor: DNAation factor-related protein 4, GLYCEROL
Authors:Park, H.H, Jeong, J.H.
Deposit date:2017-06-01
Release date:2017-07-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:CIDE domains form functionally important higher-order assemblies for DNA fragmentation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5YC1
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BU of 5yc1 by Molmil
TRAF4_GPIb complex
Descriptor: GPIb peptide, TNF receptor-associated factor 4
Authors:Park, H.H, Kim, C.M.
Deposit date:2017-09-06
Release date:2017-10-11
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Molecular basis for unique specificity of human TRAF4 for platelets GPIb beta and GPVI
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4YTO
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BU of 4yto by Molmil
Structure of coiled-coil domain of SYCP1
Descriptor: GLYCEROL, Synaptonemal complex protein 1
Authors:park, H.H.
Deposit date:2015-03-18
Release date:2016-03-23
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of coiled-coil domain of SYCP1
To Be Published
5GLG
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BU of 5glg by Molmil
The novel function of Osm1 under anaerobic condition in the ER was revealed by crystal structure of Osm1, a soluble fumarate reductase in yeast
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Fumarate reductase 2, SUCCINIC ACID
Authors:Park, H.H, Choi, J.Y.
Deposit date:2016-07-11
Release date:2017-07-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase.
Nat Commun, 9, 2018
8ENJ
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BU of 8enj by Molmil
Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)
Descriptor: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide
Authors:Park, H, Mersal, K.I.
Deposit date:2022-09-30
Release date:2023-10-18
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Eur.J.Med.Chem., 261, 2023
6U85
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BU of 6u85 by Molmil
Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates
Descriptor: Antibody Fab heavy chain, GLYCEROL, antibody Fab Light chain
Authors:Park, H, Rader, C.
Deposit date:2019-09-04
Release date:2019-11-13
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates.
Bioconjug.Chem., 30, 2019
4Y46
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BU of 4y46 by Molmil
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
Descriptor: 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea, Mitogen-activated protein kinase 10
Authors:Park, H.
Deposit date:2015-02-10
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
8YQ1
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BU of 8yq1 by Molmil
Linear form of FGF10 from Homo sapiens
Descriptor: Fibroblast growth factor 10
Authors:Park, H.J, Park, Y.S, Lee, C.E, Kang, L.W.
Deposit date:2024-03-18
Release date:2025-03-26
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:N-terminal helix formation and dimer-monomer shift of FGF10 is essential for FGF2b binding
To Be Published
1RF4
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BU of 1rf4 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase, Tetrahedral intermediate Bound State
Descriptor: (3R,4S,5R)-5-{[(1R)-1-CARBOXY-2-FLUORO-1-(PHOSPHONOOXY)ETHYL]OXY}-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 5-enolpyruvylshikimate-3-phosphate synthase
Authors:Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
Deposit date:2003-11-07
Release date:2004-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
7E9D
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BU of 7e9d by Molmil
H102A mutant of IRG1 from bacillus
Descriptor: IRG1
Authors:Park, H.H, Park, H.H.
Deposit date:2021-03-04
Release date:2021-03-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:H102A mutant of IRG1 from bacillus
To Be Published
1RF5
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BU of 1rf5 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase in Unliganded State
Descriptor: 5-enolpyruvylshikimate-3-phosphate synthase
Authors:Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
Deposit date:2003-11-07
Release date:2004-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF6
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BU of 1rf6 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase in S3P-GLP Bound State
Descriptor: 5-enolpyruvylshikimate-3-phosphate synthase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE
Authors:Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
Deposit date:2003-11-07
Release date:2004-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1SJI
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BU of 1sji by Molmil
Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization
Descriptor: Calsequestrin, cardiac muscle isoform
Authors:Park, H.J, Park, I.Y, Kim, E.J, Youn, B, Fields, K, Dunker, A.K, Kang, C.H.
Deposit date:2004-03-03
Release date:2005-03-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization.
J.Biol.Chem., 279, 2004
9B1R
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BU of 9b1r by Molmil
Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1
Authors:Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C.
Deposit date:2024-03-13
Release date:2024-05-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana.
Sci Rep, 14, 2024
4JUP
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BU of 4jup by Molmil
Dimeric structure of CARMA1 CARD
Descriptor: Caspase recruitment domain-containing protein 11
Authors:Park, H.H.
Deposit date:2013-03-25
Release date:2014-02-05
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD
Plos One, 8, 2013
7TUS
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BU of 7tus by Molmil
Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation
Descriptor: Antibody Heavy Chain, Antibody Light Chain, DI(HYDROXYETHYL)ETHER, ...
Authors:Park, H, Rader, C.
Deposit date:2022-02-03
Release date:2022-06-08
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation.
Bioconjug.Chem., 33, 2022
3TIS
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BU of 3tis by Molmil
Crystal structures of yrdA from Escherichia coli, a homologous protein of gamma-class carbonic anhydrases, show possible allosteric conformations
Descriptor: Protein YrdA, ZINC ION
Authors:Park, H.M, Chio, J.W, Lee, J.E, Jung, J.H, Kim, B.Y, Kim, J.S.
Deposit date:2011-08-21
Release date:2012-08-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the gamma-class carbonic anhydrase homologue YrdA suggest a possible allosteric switch
Acta Crystallogr.,Sect.D, 68, 2012
4DKX
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BU of 4dkx by Molmil
Crystal Structure of the Rab 6A'(Q72L)
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-6A
Authors:Park, H.H, Shin, Y.-C.
Deposit date:2012-02-04
Release date:2012-10-17
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg2+ binding with opened GTP-binding domain
Biochem.Biophys.Res.Commun., 424, 2012
1DNP
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BU of 1dnp by Molmil
STRUCTURE OF DEOXYRIBODIPYRIMIDINE PHOTOLYASE
Descriptor: 5,10-METHENYL-6,7,8-TRIHYDROFOLIC ACID, DNA PHOTOLYASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Park, H.-W, Sancar, A, Deisenhofer, J.
Deposit date:1995-07-03
Release date:1996-08-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of DNA photolyase from Escherichia coli.
Science, 268, 1995

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