7TUS

Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation

Summary for 7TUS

• Entry DOI: 10.2210/pdb7tus/pdb
• Descriptor: Antibody Heavy Chain, Antibody Light Chain, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: antibody therapeutics, antibody-drug conjugate, catalytic antibody, protein modification, engineered cysteine, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 192963.24

Authors

Park, H.,Rader, C. (deposition date: 2022-02-03, release date: 2022-06-08, Last modification date: 2023-10-18)

• Primary citation: Hwang, D.,Nilchan, N.,Park, H.,Roy, R.N.,Roush, W.R.,Rader, C.; Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation.; Bioconjug.Chem., 33:1192-1200, 2022; PubMed: 35584359; DOI: 10.1021/acs.bioconjchem.2c00146

Experimental method

X-RAY DIFFRACTION (2.4 Å)