8Z9B

Low molecular weight antigen MTB12

Summary for 8Z9B

• Entry DOI: 10.2210/pdb8z9b/pdb
• Descriptor: Low molecular weight antigen MTB12 (1 entity in total)
• Functional Keywords: antigen, secretory protein, immune system
• Biological source: Mycobacterium tuberculosis CDC1551
• Total number of polymer chains: 2
• Total formula weight: 27710.92

Authors

Park, H.H.,Han, J.H. (deposition date: 2024-04-23, release date: 2024-05-29, Last modification date: 2024-07-10)

Primary citation

Han, J.H.,Kim, D.Y.,Lee, S.Y.,Park, H.H.
Novel structure of secreted small molecular weight antigen Mtb12 from Mycobacterium tuberculosis.
Biochem.Biophys.Res.Commun., 717:150040-150040, 2024

PubMed Abstract: Mtb12, a small protein secreted by Mycobacterium tuberculosis, is known to elicit immune responses in individuals infected with the pathogen. It serves as an antigen recognized by the host's immune system. Due to its immunogenic properties and pivotal role in tuberculosis (TB) pathogenesis, Mtb12 is considered a promising candidate for TB diagnosis and vaccine development. However, the structural and functional properties of Mtb12 are largely unexplored, representing a significant gap in our understanding of M. tuberculosis biology. In this study, we present the first structure of Mtb12, which features a unique tertiary configuration consisting of four beta strands and four alpha helices. Structural analysis reveals that Mtb12 has a surface adorned with a negatively charged pocket adjacent to a central cavity. The features of these structural elements and their potential effects on the function of Mtb12 warrant further exploration. These findings offer valuable insights for vaccine design and the development of diagnostic tools.

PubMed: 38718566
DOI: 10.1016/j.bbrc.2024.150040

Experimental method

X-RAY DIFFRACTION (2.68 Å)