6U85

Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates

Summary for 6U85

• Entry DOI: 10.2210/pdb6u85/pdb
• Descriptor: Antibody Fab heavy chain, antibody Fab Light chain, GLYCEROL, ... (4 entities in total)
• Functional Keywords: single chain fv, scfv, antibody, ror2, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 48077.60

Authors

Park, H.,Rader, C. (deposition date: 2019-09-04, release date: 2019-11-13, Last modification date: 2023-10-11)

• Primary citation: Hwang, D.,Tsuji, K.,Park, H.,Burke Jr., T.R.,Rader, C.; Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates.; Bioconjug.Chem., 30:2889-2896, 2019; PubMed: 31675216; DOI: 10.1021/acs.bioconjchem.9b00609

Experimental method

X-RAY DIFFRACTION (2.78 Å)