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PDB: 87 results

6D8E
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BU of 6d8e by Molmil
Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor
Descriptor: (4-fluorophenyl)methyl {2-[(1-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate, Epidermal growth factor receptor
Authors:Park, E, Eck, M.J.
Deposit date:2018-04-26
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.537 Å)
Cite:Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Angew. Chem. Int. Ed. Engl., 57, 2018
6UCV
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BU of 6ucv by Molmil
Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer)
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, ...
Authors:Park, E, Tucker, K.
Deposit date:2019-09-17
Release date:2019-11-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution.
Nat.Struct.Mol.Biol., 26, 2019
6Q0K
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BU of 6q0k by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf
Authors:Park, E, Rawson, S, Jeon, H, Eck, M.J.
Deposit date:2019-08-01
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6Q0J
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BU of 6q0j by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Park, E, Rawson, S, Jeon, H, Eck, M.J.
Deposit date:2019-08-01
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
8DSW
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BU of 8dsw by Molmil
Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant
Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Park, E, Eck, M.J.
Deposit date:2022-07-23
Release date:2023-09-27
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural basis for oncogenic activation of the epidermal growth factor receptor by the InsFQEA exon 20 insertion
To Be Published
6Q0T
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BU of 6q0t by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Park, E, Rawson, S, Jeon, H, Eck, M.J.
Deposit date:2019-08-02
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
5TQQ
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BU of 5tqq by Molmil
Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation
Descriptor: Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E, MacKinnon, R.
Deposit date:2016-10-24
Release date:2017-01-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5TR1
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BU of 5tr1 by Molmil
Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation
Descriptor: CHOLESTEROL HEMISUCCINATE, Chloride channel protein, Monoclonal antibody, ...
Authors:Park, E, MacKinnon, R.
Deposit date:2016-10-25
Release date:2017-01-11
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
7JTX
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BU of 7jtx by Molmil
the structural basis of PTEN regulation by multi-site phosphorylation
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Authors:Park, E, Dempsey, D.R, Cole, P.
Deposit date:2020-08-18
Release date:2021-09-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:The structural basis of PTEN regulation by multi-site phosphorylation.
Nat.Struct.Mol.Biol., 28, 2021
4V4N
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BU of 4v4n by Molmil
Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein L7AE, ...
Authors:Menetret, J.F, Park, E, Gumbart, J.C, Ludtke, S.J, Li, W, Whynot, A, Rapoport, T.A, Akey, C.W.
Deposit date:2013-06-17
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
4ZJV
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BU of 4zjv by Molmil
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Eck, M.J, Park, E, Lee, B.
Deposit date:2015-04-29
Release date:2015-08-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
4WYB
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BU of 4wyb by Molmil
Structure of the Bud6 flank domain in complex with actin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Eck, M.J, Park, E, Zheng, W.
Deposit date:2014-11-17
Release date:2015-08-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
8E1M
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BU of 8e1m by Molmil
Cryo-EM structure of the endogenous core TIM23 complex from S. cerevisiae
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CARDIOLIPIN, ...
Authors:Sim, S.I, Park, E.
Deposit date:2022-08-10
Release date:2023-06-21
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of mitochondrial protein import by the TIM23 complex.
Nature, 621, 2023
8SCX
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BU of 8scx by Molmil
Cryo-EM structure of the core TIM23 complex from S. cerevisiae
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CARDIOLIPIN, ...
Authors:Sim, S.I, Park, E.
Deposit date:2023-04-05
Release date:2023-06-21
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of mitochondrial protein import by the TIM23 complex.
Nature, 621, 2023
4G4E
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BU of 4g4e by Molmil
Crystal structure of the L88A mutant of HslV from Escherichia coli
Descriptor: ATP-dependent protease subunit HslV
Authors:Lee, J.W, Park, E, Yoo, H.M, Ha, B.H, An, J.Y, Jeon, Y.J, Seol, J.H, Eom, S.H, Chung, C.H.
Deposit date:2012-07-16
Release date:2013-06-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.888 Å)
Cite:Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation
J.Mol.Biol., 425, 2013
3J45
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BU of 3j45 by Molmil
Structure of a non-translocating SecY protein channel with the 70S ribosome
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L23, 50S ribosomal protein L24, ...
Authors:Menetret, J.F, Park, E, Gumbart, J.C, Ludtke, S.J, Li, W, Whynot, A, Rapoport, T.A, Akey, C.W.
Deposit date:2013-06-18
Release date:2013-10-23
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
3J46
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BU of 3j46 by Molmil
Structure of the SecY protein translocation channel in action
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L1, 50S ribosomal protein L23P, ...
Authors:Akey, C.W, Park, E, Menetret, J.F, Gumbart, J.C, Ludtke, S.J, Li, W, Whynot, A, Rapoport, T.A.
Deposit date:2013-06-18
Release date:2013-10-23
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
8DGS
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BU of 8dgs by Molmil
Cryo-EM structure of a RAS/RAF complex (state 1)
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Eck, M.J, Jeon, H, Park, E, Rawson, S.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
8DGT
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BU of 8dgt by Molmil
Cryo-EM structure of a RAS/RAF complex (state 2)
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Eck, M.J, Jeon, H, Park, E, Rawson, S.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
6PP9
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BU of 6pp9 by Molmil
Crystal structure of BRAF:MEK1 complex
Descriptor: 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
Deposit date:2019-07-05
Release date:2019-10-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6V2U
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BU of 6v2u by Molmil
Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
Descriptor: CHLORIDE ION, Dabrafenib, Serine/threonine-protein kinase B-raf
Authors:Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
Deposit date:2019-11-25
Release date:2020-12-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.78 Å)
Cite:Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
To Be Published
6V2W
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BU of 6v2w by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
Deposit date:2019-11-25
Release date:2020-12-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7C7B
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BU of 7c7b by Molmil
Crystal structure of human TRAP1 with SJT009
Descriptor: 2-azanyl-9-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-6-chloranyl-purin-8-ol, Heat shock protein 75 kDa, mitochondrial
Authors:Kim, D, Yang, S, Yoon, N.G, Park, E, Kim, S.Y, Kang, B.H, Lee, C, Kang, S.
Deposit date:2020-05-24
Release date:2021-05-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
Acs Med.Chem.Lett., 12, 2021
7C7C
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BU of 7c7c by Molmil
Crystal structure of human TRAP1 with SJT104
Descriptor: 2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol, Heat shock protein 75 kDa, mitochondrial
Authors:Kim, D, Yang, S, Yoon, N.G, Park, E, Kim, S.Y, Kang, B.H, Lee, C, Kang, S.
Deposit date:2020-05-24
Release date:2021-05-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
Acs Med.Chem.Lett., 12, 2021
7M0Z
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BU of 7m0z by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and CH5126766
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021

221051

数据于2024-06-12公开中

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