6V2W
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP
Summary for 6V2W
Entry DOI | 10.2210/pdb6v2w/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | braf, mek1, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 76949.39 |
Authors | Li, K.,Gonzalez Del-Pino, G.,Park, E.,Eck, M.J. (deposition date: 2019-11-25, release date: 2020-12-02, Last modification date: 2023-10-11) |
Primary citation | Gonzalez-Del Pino, G.L.,Li, K.,Park, E.,Schmoker, A.M.,Ha, B.H.,Eck, M.J. Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34470822DOI: 10.1073/pnas.2107207118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
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