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6V2W

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Serine/threonine-protein kinase B-rafpolymer28332098.11UniProt (P15056)
Pfam (PF07714)
Homo sapiens (Human)Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2B
(B)
Dual specificity mitogen-activated protein kinase kinase 1polymer39743790.31UniProt (Q02750)
Pfam (PF00069)
Homo sapiens (Human)MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1
3C, E
(A, B)
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.22Chemie (ANP)
4D, F
(A, B)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
Sequence modifications
A: 445 - 723 (UniProt: P15056)
PDBExternal DatabaseDetails
Gly 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Arg 444-expression tag
B: 1 - 393 (UniProt: Q02750)
PDBExternal DatabaseDetails
Gly -3-expression tag
Gly -2-expression tag
Gly -1-expression tag
Arg 0-expression tag
Ala 218Ser 218engineered mutation
Ala 222Ser 222engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight75888.4
Non-Polymers*Number of molecules4
Total formula weight1061.0
All*Total formula weight76949.4
*Water molecules are not included.

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PDB entries from 2025-07-23

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