6V2W
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase B-raf | polymer | 283 | 32098.1 | 1 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | B (B) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 397 | 43790.3 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 3 | C, E (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A: 445 - 723 (UniProt: P15056)
B: 1 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Gly 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Arg 444 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Ala 218 | Ser 218 | engineered mutation |
| Ala 222 | Ser 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75888.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1061.0 | |
| All* | Total formula weight | 76949.4 |
