4ZJV

crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein

Summary for 4ZJV

• Entry DOI: 10.2210/pdb4zjv/pdb
• Related: 4R3P 4R3R
• Descriptor: Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1 (3 entities in total)
• Functional Keywords: epidermal growth factor receptor (egfr), erbb receptor feedback inhibitor 1, mitogen-inducible gene 6 protein(mig6), transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533; Cytoplasm : Q9UJM3
• Total number of polymer chains: 4
• Total formula weight: 90880.29

Authors

Eck, M.J.,Park, E.,Lee, B. (deposition date: 2015-04-29, release date: 2015-08-12, Last modification date: 2023-11-15)

• Primary citation: Park, E.,Kim, N.,Ficarro, S.B.,Zhang, Y.,Lee, B.I.,Cho, A.,Kim, K.,Park, A.K.,Park, W.Y.,Murray, B.,Meyerson, M.,Beroukhim, R.,Marto, J.A.,Cho, J.,Eck, M.J.; Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.; Nat.Struct.Mol.Biol., 22:703-711, 2015; PubMed: 26280531; DOI: 10.1038/nsmb.3074

Experimental method

X-RAY DIFFRACTION (2.7 Å)