4ZJV

crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Epidermal growth factor receptor	polymer	331	37636.4	2	UniProt (P00533) Pfam (PF07714)	Homo sapiens (Human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2	C, D (C, D)	ERBB receptor feedback inhibitor 1	polymer	70	7803.7	2	UniProt (Q9UJM3) Pfam (PF11555)	Homo sapiens (Human)	Mitogen-inducible gene 6 protein,MIG-6
3	E, F, G, H (A, B, C, D)	water	water		18.0	96	Chemie (HOH)

Sequence modifications

A, B: 695 - 1022 (UniProt: P00533)

PDB	External Database	Details
Gly 692	-	expression tag
Ser 693	-	expression tag
Thr 694	-	expression tag

C, D: 330 - 399 (UniProt: Q9UJM3)

PDB	External Database	Details
Cys 390	Ser 390	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	90880.3
All*	Total formula weight	90880.3

*Water molecules are not included.