4ZJV
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Epidermal growth factor receptor | polymer | 331 | 37636.4 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | C, D | ERBB receptor feedback inhibitor 1 | polymer | 70 | 7803.7 | 2 | UniProt (Q9UJM3) Pfam (PF11555) In PDB | Homo sapiens (Human) | Mitogen-inducible gene 6 protein,MIG-6 |
3 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
C, D: 330 - 399 (UniProt: Q9UJM3)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ser 693 | - | expression tag |
Thr 694 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 390 | Ser 390 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 90880.3 | |
All* | Total formula weight | 90880.3 |