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PDB: 91 件
8DNV
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BU of 8dnv by Molmil
Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1)
分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma
著者Park, E, Itskanov, S.
登録日2022-07-12
公開日2023-05-24
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNW
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BU of 8dnw by Molmil
Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2)
分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma
著者Park, E, Itskanov, S.
登録日2022-07-12
公開日2023-05-24
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO0
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BU of 8do0 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by mycolactone
分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
著者Park, E, Itskanov, S.
登録日2022-07-12
公開日2023-05-24
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO1
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BU of 8do1 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F
分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
著者Park, E, Itskanov, S.
登録日2022-07-12
公開日2023-05-24
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO2
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BU of 8do2 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA)
分子名称: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
著者Park, E, Itskanov, S.
登録日2022-07-12
公開日2023-05-24
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
6NYB
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BU of 6nyb by Molmil
Structure of a MAPK pathway complex
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ...
著者Park, E, Rawson, S, Li, K, Jeon, H, Eck, M.J.
登録日2019-02-11
公開日2019-10-09
最終更新日2020-04-22
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
7JTX
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BU of 7jtx by Molmil
the structural basis of PTEN regulation by multi-site phosphorylation
分子名称: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
著者Park, E, Dempsey, D.R, Cole, P.
登録日2020-08-18
公開日2021-09-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献The structural basis of PTEN regulation by multi-site phosphorylation.
Nat.Struct.Mol.Biol., 28, 2021
8DSW
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BU of 8dsw by Molmil
Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant
分子名称: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Park, E, Eck, M.J.
登録日2022-07-23
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structural basis for oncogenic activation of the epidermal growth factor receptor by the InsFQEA exon 20 insertion
To Be Published
6N3Q
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BU of 6n3q by Molmil
Cryo-EM structure of the yeast Sec complex
分子名称: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ...
著者Park, E, Itskanov, S.
登録日2018-11-16
公開日2018-12-19
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Structure of the posttranslational Sec protein-translocation channel complex from yeast.
Science, 363, 2019
4V4N
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BU of 4v4n by Molmil
Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein L7AE, ...
著者Menetret, J.F, Park, E, Gumbart, J.C, Ludtke, S.J, Li, W, Whynot, A, Rapoport, T.A, Akey, C.W.
登録日2013-06-17
公開日2014-07-09
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
6PP9
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BU of 6pp9 by Molmil
Crystal structure of BRAF:MEK1 complex
分子名称: 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
登録日2019-07-05
公開日2019-10-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
8SCX
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BU of 8scx by Molmil
Cryo-EM structure of the core TIM23 complex from S. cerevisiae
分子名称: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CARDIOLIPIN, ...
著者Sim, S.I, Park, E.
登録日2023-04-05
公開日2023-06-21
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis of mitochondrial protein import by the TIM23 complex.
Nature, 621, 2023
4ZJV
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BU of 4zjv by Molmil
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
分子名称: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
著者Eck, M.J, Park, E, Lee, B.
登録日2015-04-29
公開日2015-08-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
6V2U
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BU of 6v2u by Molmil
Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
分子名称: CHLORIDE ION, Dabrafenib, Serine/threonine-protein kinase B-raf
著者Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
登録日2019-11-25
公開日2020-12-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.78 Å)
主引用文献Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
To Be Published
6V2W
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BU of 6v2w by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
登録日2019-11-25
公開日2020-12-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
8E1M
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BU of 8e1m by Molmil
Cryo-EM structure of the endogenous core TIM23 complex from S. cerevisiae
分子名称: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CARDIOLIPIN, ...
著者Sim, S.I, Park, E.
登録日2022-08-10
公開日2023-06-21
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of mitochondrial protein import by the TIM23 complex.
Nature, 621, 2023
4WYB
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BU of 4wyb by Molmil
Structure of the Bud6 flank domain in complex with actin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
著者Eck, M.J, Park, E, Zheng, W.
登録日2014-11-17
公開日2015-08-19
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.493 Å)
主引用文献Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
7M0Y
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BU of 7m0y by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0Z
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BU of 7m0z by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and CH5126766
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0X
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BU of 7m0x by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and PD0325901
分子名称: CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, GLYCEROL, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0V
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BU of 7m0v by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0W
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BU of 7m0w by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0U
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BU of 7m0u by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib
分子名称: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0T
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BU of 7m0t by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib
分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ...
著者Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
登録日2021-03-11
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N74
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BU of 7n74 by Molmil
Cryo-EM structure of ATP13A2 D508N mutant in the E1-ATP-like state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, Isoform 3 of Polyamine-transporting ATPase 13A2, ...
著者Sim, S.I, Park, E.
登録日2021-06-09
公開日2021-11-10
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis of polyamine transport by human ATP13A2 (PARK9).
Mol.Cell, 81, 2021

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