8B1C
 
 | | DtpB-Nb132-ALA | | 分子名称: | ALA-LEU-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1J
 | | DtpB-Nb132-SL | | 分子名称: | DECANE, DODECANE, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B18
 | | DtpB-Nb132-AF | | 分子名称: | ALA-PHE, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B19
 | | DtpB-Nb132-AFA | | 分子名称: | ALA-PHE-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1D
 | | DtpB-Nb132-APF | | 分子名称: | ALA-PRO-PHE, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1F
 | | DtpB-Nb132-AV | | 分子名称: | ALA-VAL, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B17
 | | DtpB-Nb132-AWA | | 分子名称: | ALA-TRP-ALA, DECANE, DODECANE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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8B1H
 | | DtpB-Nb132-KV | | 分子名称: | DECANE, DODECANE, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. | | 登録日 | 2022-09-09 | | 公開日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Cell Rep, 42, 2023
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6B73
 | | Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor | | 分子名称: | CHOLESTEROL, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, Nanobody, ... | | 著者 | Che, T, Majumdar, S, Zaidi, S.A, Kormos, C, McCorvy, J.D, Wang, S, Mosier, P.D, Uprety, R, Vardy, E, Krumm, B.E, Han, G.W, Lee, M.Y, Pardon, E, Steyaert, J, Huang, X.P, Strachan, R.T, Tribo, A.R, Pasternak, G.W, Carroll, I.F, Stevens, R.C, Cherezov, V, Katritch, V, Wacker, D, Roth, B.L. | | 登録日 | 2017-10-03 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
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6RTX
 | | Crystal structure of the Patched-1 (PTCH1) ectodomain 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | | 著者 | Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. | | 登録日 | 2019-05-27 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
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8P7W
 | | Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2 | | 分子名称: | 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ATP-binding cassette sub-family G member 2, ... | | 著者 | Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P. | | 登録日 | 2023-05-31 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
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8P8J
 | | Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | | 著者 | Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P. | | 登録日 | 2023-06-01 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
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8P8A
 | | Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | | 著者 | Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P. | | 登録日 | 2023-05-31 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
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4I0C
 | | The structure of the camelid antibody cAbHuL5 in complex with human lysozyme | | 分子名称: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | | 著者 | De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M. | | 登録日 | 2012-11-16 | | 公開日 | 2013-10-09 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
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8OI2
 | | Crystal structure of Alb1 megabody in complex with human serum albumin | | 分子名称: | Alb1 Megabody, Albumin | | 著者 | De Felice, S, Zoia, G, Romanyuk, Z, Pardon, E, Steyaert, J, Angelini, A, Cendron, L. | | 登録日 | 2023-03-22 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross-reactive binding site.
Protein Sci., 33, 2024
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4KDT
 | | Structure of an early native-like intermediate of beta2-microglobulin amyloidosis | | 分子名称: | Beta-2-microglobulin, GLYCEROL, Nanobody24, ... | | 著者 | Vanderhaegen, S, Fislage, M, Pardon, E, Versees, W, Steyaert, J. | | 登録日 | 2013-04-25 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of an early native-like intermediate of beta 2-microglobulin amyloidogenesis.
Protein Sci., 22, 2013
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4KSD
 | | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | | 分子名称: | Multidrug resistance protein 1A, R2 protein | | 著者 | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | | 登録日 | 2013-05-17 | | 公開日 | 2013-07-31 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (4.1001 Å) | | 主引用文献 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
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6C9W
 | | Crystal Structure of a ligand bound LacY/Nanobody Complex | | 分子名称: | 4-nitrophenyl alpha-D-galactopyranoside, Lactose permease, Nanobody9047, ... | | 著者 | Kumar, H, Finer-Moore, J.S, Jiang, X, Smirnova, I, Kasho, V, Pardon, E, Steyaert, J, Kaback, H.R, Stroud, R.M. | | 登録日 | 2018-01-29 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal Structure of a ligand-bound LacY-Nanobody Complex.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4KSC
 | | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | | 分子名称: | Multidrug resistance protein 1A | | 著者 | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | | 登録日 | 2013-05-17 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4KSB
 | | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | | 分子名称: | Multidrug resistance protein 1A | | 著者 | Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G. | | 登録日 | 2013-05-17 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.8001 Å) | | 主引用文献 | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4KML
 | | Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody | | 分子名称: | Major prion protein, Nanobody | | 著者 | Abskharon, R.N.N, Giachin, G, Wohlkonig, A, Soror, S.H, Pardon, E, Legname, G, Steyaert, J. | | 登録日 | 2013-05-08 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody.
J.Am.Chem.Soc., 136, 2014
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