8QT9
 
 | | Cryo-EM structure of stably reduced Streptococcus pneumoniae NADPH oxidase in complex with NADH | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FAD-binding FR-type domain-containing protein, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Dubach, V.R.A, San Segundo-Acosta, P, Murphy, B.J. | | 登録日 | 2023-10-12 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | | 主引用文献 | Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase.
Nat.Struct.Mol.Biol., 2024
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5Z4B
 | | GB1 structure determination in living eukaryotic cells by in-cell NMR spectroscopy | | 分子名称: | Protein LG | | 著者 | Tanaka, T, Teppei, I, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | | 登録日 | 2018-01-10 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells.
Angew.Chem.Int.Ed.Engl., 58, 2019
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2YNP
 | | yeast betaprime COP 1-604 with KTKTN motif | | 分子名称: | COATOMER SUBUNIT BETA', KTKTN MOTIF | | 著者 | Jackson, L.P, Lewis, M, Kent, H.M, Edeling, M.A, Evans, P.R, Duden, R, Owen, D.J. | | 登録日 | 2012-10-17 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.962 Å) | | 主引用文献 | Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
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8B5F
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4KCV
 | | Pyruvate kinase (PYK) from Trypanosoma brucei soaked with 2-oxoglutaric acid | | 分子名称: | 2,6-di-O-phosphono-beta-D-fructofuranose, 2-OXOGLUTARIC ACID, GLYCEROL, ... | | 著者 | Zhong, W, Morgan, H.P, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | | 登録日 | 2013-04-24 | | 公開日 | 2014-01-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Pyruvate kinases have an intrinsic and conserved decarboxylase activity.
Biochem.J., 458, 2014
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6HGP
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8QTA
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5DHM
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5DG5
 | | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157 | | 分子名称: | Hepatocyte growth factor receptor, N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide | | 著者 | Smith, B.D, Kaufman, M.D, Leary, C.B, Turner, B.A, Wise, S.A, Ahn, Y.M, Booth, R.J, Caldwell, T.M, Ensinger, C.L, Hood, M.M, Lu, W.-P, Patt, T.W, Patt, W.C, Rutkoski, T.J, Samarakoon, T, Telikepalli, H, Vogeti, L, Vogeti, S, Yates, K.M, Chun, L, Stewart, L.J, Clare, M, Flynn, D.L. | | 登録日 | 2015-08-27 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Mol.Cancer Ther., 14, 2015
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3DD5
 | | Glomerella cingulata E600-cutinase complex | | 分子名称: | Cutinase, DIETHYL PHOSPHONATE | | 著者 | Nyon, M.P, Rice, D.W, Berrisford, J.M, Hounslow, A.M, Moir, A.J.G, Huang, H, Nathan, S, Mahadi, N.M, Farah Diba, A.B, Craven, C.J. | | 登録日 | 2008-06-05 | | 公開日 | 2008-11-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Catalysis by Glomerella cingulata Cutinase Requires Conformational Cycling between the Active and Inactive States of Its Catalytic Triad
J.Mol.Biol., 385, 2009
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3GL9
 | | The structure of a histidine kinase-response regulator complex sheds light into two-component signaling and reveals a novel cis autophosphorylation mechanism | | 分子名称: | MAGNESIUM ION, Response regulator, SULFATE ION | | 著者 | Casino, P, Rubio, V, Marina, A. | | 登録日 | 2009-03-11 | | 公開日 | 2009-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction
Cell(Cambridge,Mass.), 139, 2009
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3LMJ
 | | Structure of human anti HIV 21c Fab | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Heavy chain of anti HIV Fab from human 21c antibody, Light chain of anti HIV Fab from human 21c antibody | | 著者 | Diskin, R, Marcovecchio, P.M, Bjorkman, P.J. | | 登録日 | 2010-01-30 | | 公開日 | 2010-04-07 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Nat.Struct.Mol.Biol., 17, 2010
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3DMW
 | | Crystal structure of human type III collagen G982-G1023 containing C-terminal cystine knot | | 分子名称: | Collagen alpha-1(III) chain | | 著者 | Boudko, S.P, Engel, J, Okuyama, K, Mizuno, K, Bachinger, H.P, Schumacher, M.A. | | 登録日 | 2008-07-01 | | 公開日 | 2008-09-30 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries.
J.Biol.Chem., 283, 2008
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8QT6
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3GMD
 | | Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I | | 分子名称: | 2-methyl-3-{(3S)-1-[(1-pyridin-2-ylcyclopropyl)carbonyl]pyrrolidin-3-yl}-1H-pyrrolo[2,3-b]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Valeur, E, Lepifre, F, Roche, D, Christmann-Franck, S, Hillertz, P, Musil, D. | | 登録日 | 2009-03-13 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I.
Bioorg.Med.Chem.Lett., 22, 2012
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6UAI
 | | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with YSAM peptide | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Toth, E.A, Bryan, P.N, Orban, J. | | 登録日 | 2019-09-10 | | 公開日 | 2020-09-16 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Engineering subtilisin proteases that specifically degrade active RAS.
Commun Biol, 4, 2021
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4FXJ
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8QT7
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1QWM
 | | Structure of Helicobacter pylori catalase with formic acid bound | | 分子名称: | AZIDE ION, FORMIC ACID, KatA catalase, ... | | 著者 | Loewen, P.C, Carpena, X, Perez-Luque, R, Rovira, C, Haas, R, Odenbreit, S, Nicholls, P, Fita, I. | | 登録日 | 2003-09-02 | | 公開日 | 2004-03-30 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of Helicobacter pylori Catalase, with and without Formic Acid Bound, at 1.6 A Resolution
Biochemistry, 43, 2004
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6UBI
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7UAJ
 | | Crystal structure of apo HPV16 E6 | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Protein E6, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Shen, Q, Leonard, P.G, Cross, J.B. | | 登録日 | 2022-03-13 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Disorder-to-order transition of the interdomain linker of HPV E6 upon E6AP binding reshapes p53 binding pocket
To Be Published
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6DQ2
 | | Cronobacter sakazakii (Enterobacter sakazakii) Metallo-beta-lactamse HARLDQ motif mutant S60 | | 分子名称: | Beta-lactamase, PHOSPHATE ION | | 著者 | Monteiro Pedroso, M, Waite, D, Natasa, M, McGeary, R, Guddat, L, Hugenholtz, P, Schenk, G. | | 登録日 | 2018-06-10 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.158 Å) | | 主引用文献 | Broad spectrum antibiotic-degrading metallo-beta-lactamases are phylogenetically diverse
Protein Cell, 2020
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8BBD
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3DDL
 | | Crystallographic Structure of Xanthorhodopsin, a Light-Driven Ion Pump with Dual Chromophore | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, RETINAL, ... | | 著者 | Stagno, J, Luecke, H, Schobert, B, Lanyi, J.K, Imasheva, E.S, Wang, J.M, Balashov, S.P. | | 登録日 | 2008-06-05 | | 公開日 | 2008-10-14 | | 最終更新日 | 2016-06-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore.
Proc.Natl.Acad.Sci.USA, 105, 2008
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3PM3
 | | Bovine trypsin variant X(tripleIle227) in complex with small molecule inhibitor | | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | | 登録日 | 2010-11-16 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014
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