3GMD
Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I
Summary for 3GMD
Entry DOI | 10.2210/pdb3gmd/pdb |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-methyl-3-{(3S)-1-[(1-pyridin-2-ylcyclopropyl)carbonyl]pyrrolidin-3-yl}-1H-pyrrolo[2,3-b]pyridine, ... (5 entities in total) |
Functional Keywords | alpha/beta, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P50172 |
Total number of polymer chains | 8 |
Total formula weight | 241478.85 |
Authors | Valeur, E.,Lepifre, F.,Roche, D.,Christmann-Franck, S.,Hillertz, P.,Musil, D. (deposition date: 2009-03-13, release date: 2010-11-17, Last modification date: 2024-02-21) |
Primary citation | Valeur, E.,Christmann-Franck, S.,Lepifre, F.,Carniato, D.,Cravo, D.,Charon, C.,Bozec, S.,Musil, D.,Hillertz, P.,Doare, L.,Schmidlin, F.,Lecomte, M.,Schultz, M.,Roche, D. Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I. Bioorg.Med.Chem.Lett., 22:5909-5914, 2012 Cited by PubMed: 22901389DOI: 10.1016/j.bmcl.2012.07.070 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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