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PDB: 45 results

1AAQ
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HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
Descriptor: HIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate
Authors:Lewis, M.
Deposit date:1992-04-13
Release date:1994-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
Biochemistry, 31, 1992
6XCX
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BU of 6xcx by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with N2-((3-((2-aminoquinolin-7-yl)methoxy)phenoxy)methyl)pyridine-2,6-diamine
Descriptor: 7-{[3-(2-{[(6-aminopyridin-2-yl)methyl]amino}ethoxy)phenoxy]methyl}quinolin-2-amine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-09
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2520268 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XK8
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BU of 6xk8 by Molmil
Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-((3-((((6-aminopyridin-2-yl)methyl)amino)methyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-{[3-({[(6-aminopyridin-2-yl)methyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XK7
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BU of 6xk7 by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with 7-((3-(2-(6-aminopyridin-2-yl)ethyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-({3-[2-(6-aminopyridin-2-yl)ethyl]phenoxy}methyl)quinolin-2-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XK4
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BU of 6xk4 by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with 7-((3-(((3-(6-aminopyridin-2-yl)propyl)amino)methyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-{[3-({[4-(6-aminopyridin-2-yl)butyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XK3
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BU of 6xk3 by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with 7-((3-(((pyridin-2-ylmethyl)amino)methyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-{[3-({[(pyridin-2-yl)methyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XK6
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BU of 6xk6 by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with 7-((3-(((2-(pyridin-2-yl)ethyl)amino)methyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-{[3-({[2-(pyridin-2-yl)ethyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XK5
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BU of 6xk5 by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with 7-((3-(((4-(6-aminopyridin-2-yl)butyl)amino)methyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-{[3-({[3-(6-aminopyridin-2-yl)propyl]amino}methyl)phenoxy]methyl}quinolin-2-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6XMC
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BU of 6xmc by Molmil
Nitric Oxide Synthase from Bacillus subtilis in complex with 7-((3-(2-(6-aminopyridin-2-yl)ethyl)phenoxy)methyl)quinolin-2-amine
Descriptor: 7-({3-[2-(6-aminopyridin-2-yl)ethyl]phenoxy}methyl)quinolin-2-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Lewis, M.C, Poulos, T.L.
Deposit date:2020-06-30
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Selective Anti-MRSA inhibitors targeting Nitric Oxide Synthase
To Be Published
6DKT
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BU of 6dkt by Molmil
Crystal structure of Arginase from Bacillus subtilis
Descriptor: Arginase, MANGANESE (II) ION
Authors:Lewis, M.C, Hollingsworth, S.A, Holden, J.K, Poulos, T.L.
Deposit date:2018-05-30
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of Arginase from Bacillus subtilis at 2.08 Angstroms resolution
To Be Published
4BV4
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BU of 4bv4 by Molmil
Structure and allostery in Toll-Spatzle recognition
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN SPAETZLE C-106, PROTEIN TOLL, ...
Authors:Lewis, M.F, Arnot, C.J, Beeston, H, McCoy, A, Ashcroft, A.E, Gay, N.J, Gangloff, M.
Deposit date:2013-06-24
Release date:2013-12-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
1ZGU
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BU of 1zgu by Molmil
Solution structure of the human Mms2-Ubiquitin complex
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Lewis, M.J, Saltibus, L.F, Hau, D.D, Xiao, W, Spyracopoulos, L.
Deposit date:2005-04-22
Release date:2006-04-04
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Structural Basis for Non-Covalent Interaction Between Ubiquitin and the Ubiquitin Conjugating Enzyme Variant Human MMS2.
J.Biomol.Nmr, 34, 2006
2FKD
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BU of 2fkd by Molmil
Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor
Descriptor: Repressor protein CI
Authors:Lewis, M.
Deposit date:2006-01-04
Release date:2006-06-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis of cooperative regulation at an alternate genetic switch.
Mol.Cell, 21, 2006
2FJR
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BU of 2fjr by Molmil
Crystal Structure of Bacteriophage 186
Descriptor: Repressor protein CI
Authors:Lewis, M.
Deposit date:2006-01-03
Release date:2006-06-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structural basis of cooperative regulation at an alternate genetic switch
Mol.Cell, 21, 2006
1LBG
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BU of 1lbg by Molmil
LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY
Descriptor: DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR)
Authors:Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P.
Deposit date:1996-01-03
Release date:1996-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (4.8 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1LBH
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BU of 1lbh by Molmil
INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG
Authors:Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P.
Deposit date:1996-02-17
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1LBI
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BU of 1lbi by Molmil
LAC REPRESSOR
Descriptor: LAC REPRESSOR
Authors:Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P.
Deposit date:1996-02-17
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1AFS
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BU of 1afs by Molmil
RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE
Descriptor: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE
Authors:Bennett, M.J, Albert, R.H, Jez, J.M, Ma, H, Penning, T.M, Lewis, M.
Deposit date:1997-03-13
Release date:1997-10-08
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Structure, 5, 1997
1EFA
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BU of 1efa by Molmil
CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF
Descriptor: 2-nitrophenyl beta-D-fucopyranoside, DNA (5'-D(*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), LAC REPRESSOR
Authors:Bell, C.E, Lewis, M.
Deposit date:2000-02-07
Release date:2000-03-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A closer view of the conformation of the Lac repressor bound to operator.
Nat.Struct.Biol., 7, 2000
5G6K
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BU of 5g6k by Molmil
Structure of Bacillus subtilis Nitric Oxide Synthase I218V in complex with 7-((3-(2-(Methylamino)ethyl)phenoxy)methyl)quinolin-2- amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[3-[2-(methylamino)ethyl]phenoxy]methyl]quinolin-2-amine, CHLORIDE ION, ...
Authors:Holden, J.K, Lewis, M.C, Poulos, T.L.
Deposit date:2016-06-18
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.
Biochemistry, 55, 2016
1LRP
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BU of 1lrp by Molmil
COMPARISON OF THE STRUCTURES OF CRO AND LAMBDA REPRESSOR PROTEINS FROM BACTERIOPHAGE LAMBDA
Descriptor: LAMBDA REPRESSOR
Authors:Pabo, C, Lewis, M.
Deposit date:1987-12-04
Release date:1989-01-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda.
J.Mol.Biol., 169, 1983
2C5I
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BU of 2c5i by Molmil
N-terminal domain of tlg1 complexed with N-terminus of vps51 in distorted conformation
Descriptor: SULFATE ION, T-SNARE AFFECTING A LATE GOLGI COMPARTMENT PROTEIN 1, VACUOLAR PROTEIN SORTING PROTEIN 51
Authors:Fridmann-Sirkis, Y, Kent, H.M, Lewis, M.J, Evans, P.R, Pelham, H.R.B.
Deposit date:2005-10-27
Release date:2006-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Analysis of the Interaction between the Snare Tlg1 and Vps51.
Traffic, 7, 2006
2C5J
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BU of 2c5j by Molmil
N-terminal domain of tlg1, domain-swapped dimer
Descriptor: T-SNARE AFFECTING A LATE GOLGI COMPARTMENT PROTEIN 1
Authors:Fridmann-Sirkis, Y, Kent, H.M, Lewis, M.J, Evans, P.R, Pelham, H.R.B.
Deposit date:2005-10-27
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of the Interaction between the Snare Tlg1 and Vps51.
Traffic, 7, 2006
2C5K
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BU of 2c5k by Molmil
N-terminal domain of tlg1 complexed with N-terminus of vps51
Descriptor: SULFATE ION, T-SNARE AFFECTING A LATE GOLGI COMPARTMENT PROTEIN 1, VACUOLAR PROTEIN SORTING PROTEIN 51
Authors:Fridmann-Sirkis, Y, Kent, H.M, Lewis, M.J, Evans, P.R, Pelham, H.R.B.
Deposit date:2005-10-27
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Analysis of the Interaction between the Snare Tlg1 and Vps51.
Traffic, 7, 2006
1F39
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BU of 1f39 by Molmil
CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN
Descriptor: REPRESSOR PROTEIN CI
Authors:Bell, C.E, Frescura, P, Hochschild, A, Lewis, M.
Deposit date:2000-06-01
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.
Cell(Cambridge,Mass.), 101, 2000

 

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