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1AAQ

HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS

Summary for 1AAQ
Entry DOI10.2210/pdb1aaq/pdb
Related PRD IDPRD_000320
DescriptorHIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total)
Functional Keywordsacid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22185.22
Authors
Lewis, M. (deposition date: 1992-04-13, release date: 1994-06-22, Last modification date: 2024-02-07)
Primary citationDreyer, G.B.,Lambert, D.M.,Meek, T.D.,Carr, T.J.,Tomaszek Jr., T.A.,Fernandez, A.V.,Bartus, H.,Cacciavillani, E.,Hassell, A.M.,Minnich, M.,Petteway Jr., S.R.,Metcalf, B.W.
Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
Biochemistry, 31:6646-6659, 1992
Cited by
PubMed: 1637805
DOI: 10.1021/bi00144a004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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