4BV4

Structure and allostery in Toll-Spatzle recognition

Summary for 4BV4

• Entry DOI: 10.2210/pdb4bv4/pdb
• Descriptor: PROTEIN SPAETZLE C-106, PROTEIN TOLL, VARIABLE LYMPHOCYTE RECEPTOR B CHIMERA, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cytokine recognition, embryonic development, immune system, innate immunity, leucine-rich repeats, cystine-knot, glycoprotein
• Biological source: DROSOPHILA MELANOGASTER (FRUIT FLY); More
• Total number of polymer chains: 3
• Total formula weight: 77017.04

Authors

Lewis, M.F.,Arnot, C.J.,Beeston, H.,McCoy, A.,Ashcroft, A.E.,Gay, N.J.,Gangloff, M. (deposition date: 2013-06-24, release date: 2013-12-04, Last modification date: 2023-12-20)

• Primary citation: Lewis, M.,Arnot, C.J.,Beeston, H.,Mccoy, A.,Ashcroft, A.E.,Gay, N.J.,Gangloff, M.; Cytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation.; Proc.Natl.Acad.Sci.USA, 110:20461-, 2013; PubMed: 24282309; DOI: 10.1073/PNAS.1317002110

Experimental method

X-RAY DIFFRACTION (2.35 Å)