3UR5
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![BU of 3ur5 by Molmil](/molmil-images/mine/3ur5) | Crystal Structure of PTE mutant K185R/I274N | 分子名称: | COBALT (II) ION, DIETHYL HYDROGEN PHOSPHATE, Parathion hydrolase | 著者 | Tsai, P, Fox, N.G, Li, Y, Barondeau, D.P, Raushel, F.M. | 登録日 | 2011-11-21 | 公開日 | 2012-08-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents. Biochemistry, 51, 2012
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3BBX
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3URQ
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![BU of 3urq by Molmil](/molmil-images/mine/3urq) | Crystal Structure of PTE mutant H254G/H257W/L303T/M317L/I106C/F132I/L271I/K185R/I274N/A80V/R67H with cyclohexyl methylphosphonate inhibitor | 分子名称: | COBALT (II) ION, IMIDAZOLE, Parathion hydrolase, ... | 著者 | Tsai, P, Fox, N.G, Li, Y, Barondeau, D.P, Raushel, F.M. | 登録日 | 2011-11-22 | 公開日 | 2012-08-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents. Biochemistry, 51, 2012
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8G1W
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![BU of 8g1w by Molmil](/molmil-images/mine/8g1w) | Crystal Structure Matriptase (C731S) in Complex with Inhibitor VD4162B | 分子名称: | CHLORIDE ION, Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(KCM), Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(THZ), ... | 著者 | Lovell, S, Kashipathy, M.M, Battaile, K.P, Janetka, J.W. | 登録日 | 2023-02-03 | 公開日 | 2024-02-07 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. J.Med.Chem., 67, 2024
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6FCZ
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![BU of 6fcz by Molmil](/molmil-images/mine/6fcz) | Model of gC1q-Fc complex based on 7A EM map | 分子名称: | Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ... | 著者 | Ugurlar, D, Howes, S.C, de Kreuk, B.J.K, de Jong, R.N, Beurskens, F.J, Koster, A.J, Parren, P.W.H.I, Sharp, T.H, Gros, P, Koning, R.I. | 登録日 | 2017-12-21 | 公開日 | 2018-02-28 | 最終更新日 | 2018-10-24 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science, 359, 2018
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1S1L
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2OM7
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![BU of 2om7 by Molmil](/molmil-images/mine/2om7) | Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-bound Elongation Factors | 分子名称: | 16S ribosomal RNA (H5), 30S ribosomal protein S12, 30S ribosomal protein S2, ... | 著者 | Connell, S.R, Wilson, D.N, Rost, M, Schueler, M, Giesebrecht, J, Dabrowski, M, Mielke, T, Fucini, P, Spahn, C.M.T. | 登録日 | 2007-01-21 | 公開日 | 2008-01-15 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Mol.Cell, 25, 2007
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7JVX
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![BU of 7jvx by Molmil](/molmil-images/mine/7jvx) | Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to peptide pSDpTpTDpSDPENEPFDED) | 分子名称: | PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | 著者 | Dempsey, D, Phan, K, Cole, P, Gabelli, S.B. | 登録日 | 2020-08-24 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The structural basis of PTEN regulation by multi-site phosphorylation. Nat.Struct.Mol.Biol., 28, 2021
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7ZW1
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![BU of 7zw1 by Molmil](/molmil-images/mine/7zw1) | Human PRPH2-ROM1 hetero-dimer | 分子名称: | Nanobody, Peripherin-2, Rod outer segment membrane protein 1 | 著者 | El Mazouni, D, Gros, P. | 登録日 | 2022-05-17 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis. Sci Adv, 8, 2022
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5F8M
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6FF3
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![BU of 6ff3 by Molmil](/molmil-images/mine/6ff3) | Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I | 分子名称: | Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 | 著者 | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. | 登録日 | 2018-01-03 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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2UVQ
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![BU of 2uvq by Molmil](/molmil-images/mine/2uvq) | Crystal structure of human uridine-cytidine kinase 1 in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, URIDINE-CYTIDINE KINASE 1 | 著者 | Kosinska, U, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E.P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Uppsten, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P. | 登録日 | 2007-03-13 | 公開日 | 2007-03-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of Human Uridine-Cytidine Kinase 1 To be Published
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6SRU
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![BU of 6sru by Molmil](/molmil-images/mine/6sru) | Structure of Ig-like V-type domian of mouse Programmed cell death 1 ligand 1 (PD-L1) | 分子名称: | Programmed cell death 1 ligand 1 | 著者 | Magiera-Mularz, K, Sala, D, Grudnik, P, Holak, T.A. | 登録日 | 2019-09-06 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.532 Å) | 主引用文献 | Human and mouse PD-L1: similar molecular structure, but different druggability profiles. Iscience, 24, 2021
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2JA7
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![BU of 2ja7 by Molmil](/molmil-images/mine/2ja7) | CPD lesion containing RNA Polymerase II elongation complex C | 分子名称: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TP*TTP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', ... | 著者 | Brueckner, F, Hennecke, U, Carell, T, Cramer, P. | 登録日 | 2006-11-23 | 公開日 | 2007-02-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Cpd Damage Recognition by Transcribing RNA Polymerase II. Science, 315, 2007
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2YLO
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![BU of 2ylo by Molmil](/molmil-images/mine/2ylo) | TARGETING THE BINDING FUNCTION 3 SITE OF THE ANDROGEN RECEPTOR THROUGH IN SILICO MOLECULAR MODELING | 分子名称: | 1-[2-(4-METHYLPHENOXY)ETHYL]-2-(2-PHENOXYETHYLSULFANYL)BENZIMIDAZOLE, ANDROGEN RECEPTOR, SULFATE ION, ... | 著者 | Lack, N.A, Axerio, P, Tavassoli, P, Kuchenbecker, K, Han, F.Q, Chan, K.H, Feau, C, LeBlanc, E, Tomlinson, E, Guy, R.K, Rennie, P.S, Cherkasov, A. | 登録日 | 2011-06-04 | 公開日 | 2011-07-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Targeting the Binding Function 3 (Bf3) Site of the Human Androgen Receptor Through Virtual Screening. J.Med.Chem., 54, 2011
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7WNM
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![BU of 7wnm by Molmil](/molmil-images/mine/7wnm) | Structure of SARS-CoV-2 Gamma variant receptor-binding domain complexed with high affinity human ACE2 mutant (T27F,R273Q) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | 著者 | Ma, R.Y, Han, P.C, Wang, Q.H, Han, P. | 登録日 | 2022-01-18 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants. Signal Transduct Target Ther, 7, 2022
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6STZ
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8QF3
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5NHU
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6FBQ
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![BU of 6fbq by Molmil](/molmil-images/mine/6fbq) | Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 7.0 | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... | 著者 | McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. | 登録日 | 2017-12-19 | 公開日 | 2018-12-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Modulation of RXR-DNA complex assembly by DNA context. Mol. Cell. Endocrinol., 481, 2019
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2YLP
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![BU of 2ylp by Molmil](/molmil-images/mine/2ylp) | TARGETING THE BINDING FUNCTION 3 SITE OF THE ANDROGEN RECEPTOR THROUGH IN SILICO MOLECULAR MODELING | 分子名称: | 3-[(2,4-DICHLOROPHENYL)METHYLSULFANYLMETHYL]BENZOIC ACID, ANDROGEN RECEPTOR, SULFATE ION, ... | 著者 | Lack, N.A, Axerio, P, Tavassoli, P, Kuchenbecker, K, Han, F.Q, Chan, K.H, Feau, C, LeBlanc, E, Tomlinson, E, Guy, R.K, Rennie, P.S, Cherkasov, A. | 登録日 | 2011-06-04 | 公開日 | 2011-07-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Targeting the Binding Function 3 (Bf3) Site of the Human Androgen Receptor Through Virtual Screening. J.Med.Chem., 54, 2011
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7JL7
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![BU of 7jl7 by Molmil](/molmil-images/mine/7jl7) | Zebrafish Caspase N213T | 分子名称: | ASP-GLU-VAL-ASP peptide, Caspase 3, apoptosis-related cysteine protease a | 著者 | Clark, A.C, Swartz, P.D. | 登録日 | 2020-07-29 | 公開日 | 2021-01-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3. Biosci.Rep., 41, 2021
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4PEG
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![BU of 4peg by Molmil](/molmil-images/mine/4peg) | Dbr1 in complex with guanosine-5'-monophosphate | 分子名称: | GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... | 著者 | Montemayor, E.J, Katolik, A, Clark, N.E, Taylor, A.B, Schuermann, J.P, Combs, D.J, Johnsson, R, Holloway, S.P, Stevens, S.W, Damha, M.J, Hart, P.J. | 登録日 | 2014-04-23 | 公開日 | 2014-08-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res., 42, 2014
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6IXT
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![BU of 6ixt by Molmil](/molmil-images/mine/6ixt) | Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and Mg2+ | 分子名称: | GLYCEROL, Isocitrate dehydrogenase, MAGNESIUM ION, ... | 著者 | Zhu, G.P, Tang, W.G, Wang, P. | 登録日 | 2018-12-12 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys., 708, 2021
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8QF5
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