2WWR
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![BU of 2wwr by Molmil](/molmil-images/mine/2wwr) | Crystal Structure of Human Glyoxylate Reductase Hydroxypyruvate Reductase | Descriptor: | GLYOXYLATE REDUCTASE/HYDROXYPYRUVATE REDUCTASE, MAGNESIUM ION | Authors: | Booth, M.P.S, Conners, R, Rumsby, G, Brady, R.L. | Deposit date: | 2009-10-26 | Release date: | 2010-10-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Structural Basis of Substrate Specificity in Human Glyoxylate Reductase/Hydroxypyruvate Reductase. J.Mol.Biol., 360, 2006
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3MB4
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![BU of 3mb4 by Molmil](/molmil-images/mine/3mb4) | Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP | Descriptor: | 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, CHLORIDE ION, ... | Authors: | Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2010-03-25 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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3R1A
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![BU of 3r1a by Molmil](/molmil-images/mine/3r1a) | Closed crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene | Descriptor: | (4-tert-butylphenyl)acetaldehyde, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Gay, S.C, Zhang, H, Stout, C.D, Hollenberg, P.F, Halpert, J.R. | Deposit date: | 2011-03-09 | Release date: | 2011-05-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity. Biochemistry, 50, 2011
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2WYO
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![BU of 2wyo by Molmil](/molmil-images/mine/2wyo) | Trypanosoma brucei glutathione synthetase | Descriptor: | GLUTATHIONE, GLUTATHIONE SYNTHETASE, SULFATE ION | Authors: | Fyfe, P.K, Alphey, M.S, Hunter, W.N. | Deposit date: | 2009-11-17 | Release date: | 2010-01-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structure of Trypanosoma Brucei Glutathione Synthetase; Domain and Loop Alterations in the Catalytic Cycle of a Highly Conserved Enzyme. Mol.Biochem.Parasitol., 170, 2010
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1T7X
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![BU of 1t7x by Molmil](/molmil-images/mine/1t7x) | Zn-alpha-2-glycoprotein; refolded CHO-ZAG PEG 400 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Zinc-alpha-2-glycoprotein | Authors: | Delker, S.L, West Jr, A.P, McDermott, L, Kennedy, M.W, Bjorkman, P.J. | Deposit date: | 2004-05-11 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein. J.Struct.Biol., 148, 2004
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2PXQ
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![BU of 2pxq by Molmil](/molmil-images/mine/2pxq) | Variant 14 of Ribonucleoprotein Core of the E. Coli Signal Recognition Particle | Descriptor: | 4.5 S RNA, COBALT HEXAMMINE(III), Signal recognition particle protein | Authors: | Keel, A.Y, Rambo, R.P, Batey, R.T, Kieft, J.S. | Deposit date: | 2007-05-14 | Release date: | 2007-08-07 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A General Strategy to Solve the Phase Problem in RNA Crystallography. Structure, 15, 2007
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3BBE
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![BU of 3bbe by Molmil](/molmil-images/mine/3bbe) | M. jannaschii Nep1 | Descriptor: | GLYCEROL, Ribosome biogenesis protein NEP1-like | Authors: | Taylor, A.B, Meyer, B, Leal, B.Z, Kotter, P, Hart, P.J, Entian, K.-D, Wohnert, J. | Deposit date: | 2007-11-09 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. Nucleic Acids Res., 36, 2008
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1K0N
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![BU of 1k0n by Molmil](/molmil-images/mine/1k0n) | Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione | Descriptor: | CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1, GLUTATHIONE | Authors: | Harrop, S.J, DeMaere, M.Z, Fairlie, W.D, Reztsova, T, Valenzuela, S.M, Mazzanti, M, Tonini, R, Qiu, M.R, Jankova, L, Warton, K, Bauskin, A.R, Wu, W.M, Pankhurst, S, Campbell, T.J, Breit, S.N, Curmi, P.M.G. | Deposit date: | 2001-09-19 | Release date: | 2001-12-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. J.Biol.Chem., 276, 2001
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2Q06
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![BU of 2q06 by Molmil](/molmil-images/mine/2q06) | Crystal structure of Influenza A Virus H5N1 Nucleoprotein | Descriptor: | Nucleoprotein | Authors: | Ng, A.K.L, Zhang, H, Tan, K, Wang, J, Shaw, P.C. | Deposit date: | 2007-05-21 | Release date: | 2008-05-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. Faseb J., 22, 2008
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2X7G
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![BU of 2x7g by Molmil](/molmil-images/mine/2x7g) | Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, PURVALANOL B, ... | Authors: | Pike, A.C.W, Savitsky, P, Fedorov, O, Krojer, T, Ugochukwu, E, von Delft, F, Gileadi, O, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, Knapp, S. | Deposit date: | 2010-02-26 | Release date: | 2010-04-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (Srpk2) Bound to Purvalanol B To be Published
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5CYI
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![BU of 5cyi by Molmil](/molmil-images/mine/5cyi) | CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300) | Descriptor: | 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 | Authors: | Anscombe, E, Meschini, E, Vidal, R.M, Martin, M.P, Staunton, D, Geitmann, M, Danielson, U.H, Stanley, W.A, Wang, L.Z, Reuillon, T, Golding, B.T, Cano, C, Newell, D.R, Noble, M.E.M, Wedge, S.R, Endicott, J.A, Griffin, R.J. | Deposit date: | 2015-07-30 | Release date: | 2015-09-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem.Biol., 22, 2015
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1Z1H
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![BU of 1z1h by Molmil](/molmil-images/mine/1z1h) | HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3 | Descriptor: | N-{(2R)-2-HYDROXY-2-[(8S,11S)-8-ISOPROPYL-6,9-DIOXO-2-OXA-7,10-DIAZABICYCLO[11.2.2]HEPTADECA-1(15),13,16-TRIEN-11-YL]ETHYL}-N-ISOPENTYLBENZENESULFONAMIDE, Pol polyprotein, SULFATE ION | Authors: | Martin, J.L, Begun, J, Schindeler, A, Wickramasinghe, W.A, Alewood, D, Alewood, P.F, Bergman, D.A, Brinkworth, R.I, Abbenante, G, March, D.R, Reid, R.C, Fairlie, D.P. | Deposit date: | 2005-03-04 | Release date: | 2005-03-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease Biochemistry, 38, 1999
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1Z1W
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![BU of 1z1w by Molmil](/molmil-images/mine/1z1w) | Crystal structures of the tricorn interacting facor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations | Descriptor: | SULFATE ION, Tricorn protease interacting factor F3, ZINC ION | Authors: | Kyrieleis, O.J.P, Goettig, P, Kiefersauer, R, Huber, R, Brandstetter, H. | Deposit date: | 2005-03-07 | Release date: | 2005-05-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations J.MOL.BIOL., 394, 2005
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2OTO
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![BU of 2oto by Molmil](/molmil-images/mine/2oto) | |
1G0T
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![BU of 1g0t by Molmil](/molmil-images/mine/1g0t) | DSBC MUTANT C101S | Descriptor: | DI(HYDROXYETHYL)ETHER, THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC | Authors: | Haebel, P.W, Metcalf, P. | Deposit date: | 2000-10-09 | Release date: | 2003-02-04 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the protein disulfide bond isomerase, DsbC, from Escherichia coli Embo J., 21, 2002
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2X5Y
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![BU of 2x5y by Molmil](/molmil-images/mine/2x5y) | Human ZC3HAV1 (ARTD13), C-terminal domain | Descriptor: | ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1 | Authors: | Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Kraulis, P, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H. | Deposit date: | 2010-02-11 | Release date: | 2010-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structural Basis for Lack of Adp-Ribosyltransferase Activity in Poly(Adp-Ribose) Polymerase-13/Zinc Finger Antiviral Protein. J.Biol.Chem., 290, 2015
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1PY4
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![BU of 1py4 by Molmil](/molmil-images/mine/1py4) | Beta2 microglobulin mutant H31Y displays hints for amyloid formations | Descriptor: | Beta-2-microglobulin precursor | Authors: | Rosano, C, Zuccotti, S, Mangione, P, Giorgetti, S, Bellotti, V, Pettirossi, F, Corazza, A, Viglino, P, Esposito, G, Bolognesi, M. | Deposit date: | 2003-07-08 | Release date: | 2004-05-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation J.Mol.Biol., 335, 2004
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1TCO
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![BU of 1tco by Molmil](/molmil-images/mine/1tco) | TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS) | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, FE (III) ION, ... | Authors: | Griffith, J.P, Kim, J.L, Kim, E.E, Sintchak, M.D, Thomson, J.A, Fitzgibbon, M.J, Fleming, M.A, Caron, P.R, Hsiao, K, Navia, M.A. | Deposit date: | 1996-08-21 | Release date: | 1997-02-12 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell(Cambridge,Mass.), 82, 1995
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5D80
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![BU of 5d80 by Molmil](/molmil-images/mine/5d80) | Crystal Structure of Yeast V1-ATPase in the Autoinhibited Form | Descriptor: | V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit D, ... | Authors: | Oot, R.A, Kane, P.M, Berry, E.A, Wilkens, S. | Deposit date: | 2015-08-14 | Release date: | 2016-06-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (6.202 Å) | Cite: | Crystal structure of yeast V1-ATPase in the autoinhibited state. Embo J., 35, 2016
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1PKL
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![BU of 1pkl by Molmil](/molmil-images/mine/1pkl) | THE STRUCTURE OF LEISHMANIA PYRUVATE KINASE | Descriptor: | PROTEIN (PYRUVATE KINASE), SULFATE ION | Authors: | Rigden, D.J, Phillips, S.E.V, Michels, P.A.M, Fothergill-Gilmore, L.A. | Deposit date: | 1998-09-15 | Release date: | 1998-09-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity. J.Mol.Biol., 291, 1999
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1GKA
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![BU of 1gka by Molmil](/molmil-images/mine/1gka) | The molecular basis of the coloration mechanism in lobster shell. beta-crustacyanin at 3.2 A resolution | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ASTAXANTHIN, ... | Authors: | Cianci, M, Rizkallah, P.J, Olczak, A, Raftery, J, Chayen, N.E, Zagalsky, P.F, Helliwell, J.R. | Deposit date: | 2001-08-10 | Release date: | 2002-08-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | The Molecular Basis of the Coloration Mechanism in Lobster Shell: Beta -Crustacyanin at 3.2-A Resolution Proc.Natl.Acad.Sci.USA, 99, 2002
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2OVX
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![BU of 2ovx by Molmil](/molmil-images/mine/2ovx) | MMP-9 active site mutant with barbiturate inhibitor | Descriptor: | 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Tochowicz, A, Bode, W, Maskos, K, Goettig, P. | Deposit date: | 2007-02-15 | Release date: | 2007-06-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity. J.Mol.Biol., 371, 2007
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2OXE
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![BU of 2oxe by Molmil](/molmil-images/mine/2oxe) | Structure of the Human Pancreatic Lipase-related Protein 2 | Descriptor: | CALCIUM ION, CHLORIDE ION, Pancreatic lipase-related protein 2, ... | Authors: | Walker, J.R, Davis, T, Seitova, A, Finerty Jr, P.J, Butler-Cole, C, Kozieradzki, I, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-02-20 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation. Biochemistry, 47, 2008
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2H4V
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![BU of 2h4v by Molmil](/molmil-images/mine/2h4v) | Crystal Structure of the Human Tyrosine Receptor Phosphatase Gamma | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Ugochukwu, E, Barr, A, Das, S, Eswaran, J, Savitsky, P, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Debreczeni, J, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-05-25 | Release date: | 2006-07-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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1T7Z
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![BU of 1t7z by Molmil](/molmil-images/mine/1t7z) | Zn-alpha-2-glycoprotein; baculo-ZAG no PEG, no glycerol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Zinc-alpha-2-glycoprotein | Authors: | Delker, S.L, West Jr, A.P, McDermott, L, Kennedy, M.W, Bjorkman, P.J. | Deposit date: | 2004-05-11 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein. J.Struct.Biol., 148, 2004
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