3R1A
Closed crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene
Summary for 3R1A
Entry DOI | 10.2210/pdb3r1a/pdb |
Related | 3R1B |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, (4-tert-butylphenyl)acetaldehyde, ... (4 entities in total) |
Functional Keywords | cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, t302 covalently linked to tert-butylphenylacetylene, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 8 |
Total formula weight | 439694.59 |
Authors | Gay, S.C.,Zhang, H.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R. (deposition date: 2011-03-09, release date: 2011-05-11, Last modification date: 2023-09-13) |
Primary citation | Gay, S.C.,Zhang, H.,Wilderman, P.R.,Roberts, A.G.,Liu, T.,Li, S.,Lin, H.L.,Zhang, Q.,Woods, V.L.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R. Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity. Biochemistry, 50:4903-4911, 2011 Cited by PubMed: 21510666DOI: 10.1021/bi200482g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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