7PWZ
| Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 | 分子名称: | 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... | 著者 | Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. | 登録日 | 2021-10-07 | 公開日 | 2022-12-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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7PWT
| Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptor alpha phosphopeptide, stabilised by pyrrolidone derivative 228 | 分子名称: | (2~{R})-1-(2-hydroxyphenyl)-2-(4-nitrophenyl)-4-oxidanyl-3-(phenylcarbonyl)-2~{H}-pyrrol-5-one, 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, ... | 著者 | Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. | 登録日 | 2021-10-07 | 公開日 | 2022-12-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.312 Å) | 主引用文献 | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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4Y5I
| Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau | 著者 | Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C. | 登録日 | 2015-02-11 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
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5HF3
| Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma | 分子名称: | 14-3-3 protein sigma, modified Tau peptide | 著者 | Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. | 登録日 | 2016-01-06 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
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7QI1
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8C1Y
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5JM4
| Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain | 分子名称: | 14-3-3 protein zeta/delta, BENZOIC ACID, GLN-GLY-MKD-ANG-ASP-MKD-LEU-ASP-LEU-ALA-CLU | 著者 | Bier, D, Krueger, D, Glas, A, Wallraven, K, Ottmann, C, Hennig, S, Grossmann, T. | 登録日 | 2016-04-28 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions. J. Med. Chem., 60, 2017
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5EXA
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8BZH
| FC-NAc stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8BZD
| deAc-FC stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, De-acetylated Fusicoccin, ERalpha peptide, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8BZE
| FC-J stabilizer for ERa and 14-3-3 | 分子名称: | (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-4,9-bis(oxidanyl)-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]oxy]-6-(2-methylbut-3-en-2-yloxymethyl)oxane-3,4,5-triol, 14-3-3 protein sigma, ERalpha peptide, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a new potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8BZG
| FC-31 stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, Fusicoccin 31, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8BZT
| FC-NAg stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-15 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8C0L
| FC-THF stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, Fusicoccin A-THF | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-17 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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5EWZ
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5EC9
| Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2 | 分子名称: | 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha | 著者 | Leysen, S, Ottmann, C, Schafer, A, Scheepstra, M, Brunsveld, L, Sunden, R, Ma, J.N, Burnstein, E.S, Olsson, R. | 登録日 | 2015-10-20 | 公開日 | 2016-03-09 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation. J.Med.Chem., 59, 2016
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4JDD
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4JC3
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3LW1
| Binary complex of 14-3-3 sigma and p53 pT387-peptide | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Schumacher, B, Mondry, J, Thiel, P, Weyand, M, Ottmann, C. | 登録日 | 2010-02-23 | 公開日 | 2010-03-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer Febs Lett., 584, 2010
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4J24
| Estrogen Receptor in complex with proline-flanked LXXLL peptides | 分子名称: | 19-mer peptide, ESTRADIOL, Estrogen receptor beta | 著者 | Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L. | 登録日 | 2013-02-04 | 公開日 | 2013-03-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction J.Am.Chem.Soc., 135, 2013
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6TJM
| Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by Pyrrolidone1 | 分子名称: | 14-3-3 protein sigma, 5-[(2~{R})-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid, C-terminal phosphopeptide of human estrogen receptor alpha, ... | 著者 | Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. | 登録日 | 2019-11-26 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
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3MHR
| 14-3-3 sigma in complex with YAP pS127-peptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C. | 登録日 | 2010-04-08 | 公開日 | 2010-09-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution Acta Crystallogr.,Sect.F, 66, 2010
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6TL3
| Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by a Pyrrolidone1 derivative | 分子名称: | 14-3-3 protein sigma, 5-[(2~{S},3~{R})-3-[(~{R})-azanyl(phenyl)methyl]-2-(4-nitrophenyl)-4,5-bis(oxidanylidene)pyrrolidin-1-yl]-2-oxidanyl-benzoic acid, Estrogen receptor | 著者 | Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. | 登録日 | 2019-11-30 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.455 Å) | 主引用文献 | Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
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6TCH
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4J26
| Estrogen Receptor in complex with proline-flanked LXXLL peptides | 分子名称: | 12-mer Peptide, ESTRADIOL, Estrogen receptor beta | 著者 | Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L. | 登録日 | 2013-02-04 | 公開日 | 2013-03-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction J.Am.Chem.Soc., 135, 2013
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