6TCH

Binary complex of 14-3-3 sigma and a high-affinity non-canonical 9-mer peptide binder

Summary for 6TCH

Entry DOI	10.2210/pdb6tch/pdb
Descriptor	14-3-3 protein sigma, DLY-NVA-PPN-KCJ-SEP-PPN-B3S-BAL-PPN-LYS, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	non-canonical peptide, 14-3-3 protein sigma, protein-peptide interaction, phosphopeptide, non-natural amino acids, protein binding, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28116.05
Authors	Somsen, B.A.,Ottmann, C. (deposition date: 2019-11-06, release date: 2020-07-01, Last modification date: 2024-01-24)
Primary citation	Quartararo, A.J.,Gates, Z.P.,Somsen, B.A.,Hartrampf, N.,Ye, X.,Shimada, A.,Kajihara, Y.,Ottmann, C.,Pentelute, B.L. Ultra-large chemical libraries for the discovery of high-affinity peptide binders. Nat Commun, 11:3183-3183, 2020 Cited by PubMed: 32576815 DOI: 10.1038/s41467-020-16920-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.801 Å)

Structure validation