6TCH
Binary complex of 14-3-3 sigma and a high-affinity non-canonical 9-mer peptide binder
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0001836 | biological_process | release of cytochrome c from mitochondria |
| B | 0003334 | biological_process | keratinocyte development |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006469 | biological_process | negative regulation of protein kinase activity |
| B | 0006611 | biological_process | protein export from nucleus |
| B | 0007165 | biological_process | signal transduction |
| B | 0008104 | biological_process | protein localization |
| B | 0008426 | molecular_function | protein kinase C inhibitor activity |
| B | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| B | 0010482 | biological_process | regulation of epidermal cell division |
| B | 0010737 | biological_process | protein kinase A signaling |
| B | 0010839 | biological_process | negative regulation of keratinocyte proliferation |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022407 | biological_process | regulation of cell-cell adhesion |
| B | 0030216 | biological_process | keratinocyte differentiation |
| B | 0030307 | biological_process | positive regulation of cell growth |
| B | 0031424 | biological_process | keratinization |
| B | 0032880 | biological_process | regulation of protein localization |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043588 | biological_process | skin development |
| B | 0043616 | biological_process | keratinocyte proliferation |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0045606 | biological_process | positive regulation of epidermal cell differentiation |
| B | 0045785 | biological_process | positive regulation of cell adhesion |
| B | 0045824 | biological_process | negative regulation of innate immune response |
| B | 0046827 | biological_process | positive regulation of protein export from nucleus |
| B | 0050815 | molecular_function | phosphoserine residue binding |
| B | 0051219 | molecular_function | phosphoprotein binding |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0061436 | biological_process | establishment of skin barrier |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0072089 | biological_process | stem cell proliferation |
| B | 0140311 | molecular_function | protein sequestering activity |
| B | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
| B | 1903829 | biological_process | positive regulation of protein localization |
| B | 2000647 | biological_process | negative regulation of stem cell proliferation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 301 |
| Chain | Residue |
| B | SER37 |
| B | GLU39 |
| B | HOH696 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| B | HOH705 |
| B | HOH705 |
| B | GLU2 |
| B | GLU2 |
| B | HOH424 |
| B | HOH424 |
| B | HOH620 |
| B | HOH620 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 303 |
| Chain | Residue |
| B | GLU35 |
| B | GLU110 |
| B | GLU188 |
| B | HOH562 |
| B | HOH569 |
| B | HOH601 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 304 |
| Chain | Residue |
| B | GLU75 |
| B | GLU161 |
| B | HOH554 |
| B | HOH573 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 305 |
| Chain | Residue |
| B | LYS9 |
| B | HOH684 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residues NVA A 1 and PPN A 2 |
| Chain | Residue |
| A | KCJ3 |
| A | SEP4 |
| A | HOH109 |
| B | ARG56 |
| B | ALA57 |
| B | ARG60 |
| B | HOH466 |
| B | HOH539 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residues PPN A 2 and KCJ A 3 |
| Chain | Residue |
| A | NVA1 |
| A | SEP4 |
| A | HOH105 |
| A | HOH109 |
| B | ARG56 |
| B | ALA57 |
| B | ARG60 |
| B | LEU174 |
| B | VAL178 |
| B | GLU182 |
| B | ASN226 |
| B | LEU229 |
| B | HOH539 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residues KCJ A 3 and SEP A 4 |
| Chain | Residue |
| A | NVA1 |
| A | PPN2 |
| A | PPN5 |
| A | HOH101 |
| A | HOH104 |
| A | HOH105 |
| A | HOH106 |
| A | HOH108 |
| A | HOH109 |
| B | ARG56 |
| B | ARG129 |
| B | TYR130 |
| B | LEU174 |
| B | ASN175 |
| B | VAL178 |
| B | GLU182 |
| B | ASN226 |
| B | LEU229 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residues SEP A 4 and PPN A 5 |
| Chain | Residue |
| A | PPN2 |
| A | KCJ3 |
| A | B3S6 |
| A | BAL7 |
| A | PPN8 |
| A | HOH101 |
| A | HOH104 |
| A | HOH105 |
| A | HOH106 |
| A | HOH108 |
| A | HOH109 |
| B | ARG56 |
| B | LYS122 |
| B | ARG129 |
| B | TYR130 |
| B | LEU174 |
| B | ASN175 |
| B | ILE219 |
| B | LEU222 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residues PPN A 5 and B3S A 6 |
| Chain | Residue |
| A | SEP4 |
| A | BAL7 |
| A | PPN8 |
| A | HOH101 |
| A | HOH102 |
| A | HOH103 |
| A | HOH110 |
| B | SER45 |
| B | LYS122 |
| B | LEU174 |
| B | ASN175 |
| B | ILE219 |
| B | LEU222 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residues B3S A 6 and BAL A 7 |
| Chain | Residue |
| A | HOH110 |
| B | ASN42 |
| B | SER45 |
| B | LYS122 |
| A | PPN5 |
| A | PPN8 |
| A | HOH101 |
| A | HOH102 |
| A | HOH103 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residues BAL A 7 and PPN A 8 |
| Chain | Residue |
| A | PPN5 |
| A | B3S6 |
| A | LYS9 |
| A | NH210 |
| A | HOH103 |
| B | ASN42 |
| B | SER45 |
| B | PHE119 |
| B | LYS122 |
| B | PRO167 |
| B | GLY171 |
Functional Information from PROSITE/UniProt
| site_id | PS00796 |
| Number of Residues | 11 |
| Details | 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV |
| Chain | Residue | Details |
| B | ARG41-VAL51 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interaction with phosphoserine on interacting protein |
| Chain | Residue | Details |
| B | ARG56 | |
| B | ARG129 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| B | SER5 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER74 |
