5HVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hvw by Molmil](/molmil-images/mine/5hvw) | Monomeric IgG4 Fc | Descriptor: | GLYCEROL, Ig gamma-4 chain C region, ZINC ION, ... | Authors: | Oganesyan, V.Y, Shan, L, Dall'Acqua, W.F. | Deposit date: | 2016-01-28 | Release date: | 2016-08-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Generation and Characterization of an IgG4 Monomeric Fc Platform. Plos One, 11, 2016
|
|
1EUE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1eue by Molmil](/molmil-images/mine/1eue) | RAT OUTER MITOCHONDRIAL MEMBRANE CYTOCHROME B5 | Descriptor: | CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Oganesyan, V, Zhang, X. | Deposit date: | 2000-04-19 | Release date: | 2001-04-04 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Modulation of redox potential in electron transfer proteins: effects of complex formation on the active site microenvironment of cytochrome b5. FARADAY DISC.CHEM.SOC, 116, 2001
|
|
3SKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3skj by Molmil](/molmil-images/mine/3skj) | Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody | Descriptor: | Antibody, heavy chain, light chain, ... | Authors: | Oganesyan, V.Y, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2011-06-22 | Release date: | 2011-08-31 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody. J.Mol.Biol., 413, 2011
|
|
1LQV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1lqv by Molmil](/molmil-images/mine/1lqv) | Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Endothelial protein C receptor, ... | Authors: | Oganesyan, V, Oganesyan, N, Terzyan, S, Dongfeng, Q, Dauter, Z, Esmon, N.L, Esmon, C.T. | Deposit date: | 2002-05-13 | Release date: | 2002-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of the endothelial protein C receptor and a bound phospholipid. J.Biol.Chem., 277, 2002
|
|
8TJF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8tjf by Molmil](/molmil-images/mine/8tjf) | monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface | Descriptor: | Fab Lambda light chain, IgG1 Fab heavy chain | Authors: | Oganesyan, V.Y, van Dyk, N, Mazor, Y, Chiang, C. | Deposit date: | 2023-07-21 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15, 2023
|
|
8TI4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ti4 by Molmil](/molmil-images/mine/8ti4) | monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface | Descriptor: | GLYCEROL, IgG1 Fab heavy chain, mutated to promote correct pairing, ... | Authors: | Oganesyan, V.Y, van Dyk, N, Mazor, Y. | Deposit date: | 2023-07-19 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15, 2023
|
|
8SUO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8suo by Molmil](/molmil-images/mine/8suo) | BA.2/AZD1061/AZD3152 structure analysis | Descriptor: | AZD1061 heavy chain, AZD1061 light chain, AZD3152 heavy chain, ... | Authors: | Oganesyan, V, van Dyk, N, Dippel, A, Barnes, A, O'Connor, E. | Deposit date: | 2023-05-12 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | X-ray crystal structure of BA.2 RBD bound by two neutralizing antibodies To Be Published
|
|
1T8B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t8b by Molmil](/molmil-images/mine/1t8b) | Crystal structure of refolded PHOU-like protein (gi 2983430) from Aquifex aeolicus | Descriptor: | Phosphate transport system protein phoU homolog | Authors: | Oganesyan, V, Kim, S.-H, Oganesyan, N, Jancarik, J, Adams, P.D, Kim, R, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-05-11 | Release date: | 2004-12-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Crystal structure of the "PhoU-like" phosphate uptake regulator from Aquifex aeolicus. J.Bacteriol., 187, 2005
|
|
1L8J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1l8j by Molmil](/molmil-images/mine/1l8j) | Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, ... | Authors: | Oganesyan, V, Oganesyan, N, Terzyan, S, Dongfeng, Q, Dauter, Z, Esmon, N.L, Esmon, C.T. | Deposit date: | 2002-03-20 | Release date: | 2002-06-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of the endothelial protein C receptor and a bound phospholipid. J.Biol.Chem., 277, 2002
|
|
1T72
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t72 by Molmil](/molmil-images/mine/1t72) | Crystal structure of phosphate transport system protein phoU from Aquifex aeolicus | Descriptor: | Phosphate transport system protein phoU homolog | Authors: | Oganesyan, V, Kim, S.-H, Oganesyan, N, Jancarik, J, Adams, P.D, Kim, R, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-05-07 | Release date: | 2004-12-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the "PhoU-like" phosphate uptake regulator from Aquifex aeolicus. J.Bacteriol., 187, 2005
|
|
1MJW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mjw by Molmil](/molmil-images/mine/1mjw) | STRUCTURE OF INORGANIC PYROPHOSPHATASE MUTANT D42N | Descriptor: | INORGANIC PYROPHOSPHATASE, SULFATE ION | Authors: | Oganesyan, V, Harutyunyan, E.H, Avaeva, S.M, Samygina, V.R, Huber, R. | Deposit date: | 1997-02-08 | Release date: | 1997-12-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97. Biochemistry Mosc., 63, 1998
|
|
1MJY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mjy by Molmil](/molmil-images/mine/1mjy) | STRUCTURE OF INORGANIC PYROPHOSPHATASE MUTANT D70N | Descriptor: | INORGANIC PYROPHOSPHATASE | Authors: | Oganesyan, V, Harutyunyan, E.H, Avaeva, S.M, Huber, R. | Deposit date: | 1997-02-08 | Release date: | 1997-12-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97. Biochemistry Mosc., 63, 1998
|
|
1MJX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mjx by Molmil](/molmil-images/mine/1mjx) | STRUCTURE OF INORGANIC PYROPHOSPHATASE MUTANT D65N | Descriptor: | INORGANIC PYROPHOSPHATASE, SULFATE ION | Authors: | Oganesyan, V, Harutyunyan, E.H, Avaeva, S.M, Huber, R. | Deposit date: | 1997-02-08 | Release date: | 1997-12-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97. Biochemistry Mosc., 63, 1998
|
|
7R8U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7r8u by Molmil](/molmil-images/mine/7r8u) | |
3FJT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fjt by Molmil](/molmil-images/mine/3fjt) | Crystal structure of a human Fc fragment engineered for extended serum half-life | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2008-12-15 | Release date: | 2009-03-24 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural characterization of a human Fc fragment engineered for extended serum half-life. Mol.Immunol., 46, 2009
|
|
1OZ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1oz9 by Molmil](/molmil-images/mine/1oz9) | Crystal structure of AQ_1354, a hypothetical protein from Aquifex aeolicus | Descriptor: | Hypothetical protein AQ_1354 | Authors: | Oganesyan, V, Busso, D, Brandsen, J, Chen, S, Jancarik, J, Kim, R, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2003-04-08 | Release date: | 2003-09-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.894 Å) | Cite: | Structure of the hypothetical protein AQ_1354 from Aquifex aeolicus. Acta Crystallogr.,Sect.D, 59, 2003
|
|
4ZNE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4zne by Molmil](/molmil-images/mine/4zne) | IgG1 Fc-FcgammaRI ecd complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Oganesyan, V.Y, Dall'Acqua, W.F. | Deposit date: | 2015-05-04 | Release date: | 2015-11-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Structural insights into the interaction of human IgG1 with Fc gamma RI: no direct role of glycans in binding. Acta Crystallogr.,Sect.D, 71, 2015
|
|
2QL1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ql1 by Molmil](/molmil-images/mine/2ql1) | Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment | Descriptor: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2007-07-12 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.534 Å) | Cite: | Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45, 2008
|
|
4UB0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ub0 by Molmil](/molmil-images/mine/4ub0) | |
4U6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4u6v by Molmil](/molmil-images/mine/4u6v) | Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody | Descriptor: | Alpha-hemolysin, Fab, antigen binding fragment, ... | Authors: | Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2014-07-29 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody. J.Biol.Chem., 289, 2014
|
|
2HEK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2hek by Molmil](/molmil-images/mine/2hek) | Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution. | Descriptor: | BROMIDE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Oganesyan, V, Jancarik, J, Adams, P.D, Kim, R, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2006-06-21 | Release date: | 2006-07-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus. Acta Crystallogr.,Sect.F, 63, 2007
|
|
6WIB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wib by Molmil](/molmil-images/mine/6wib) | Next generation monomeric IgG4 Fc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 4, ZINC ION | Authors: | Oganesyan, V.Y, Shan, L, Dall'Acqua, W, van Dyk, N. | Deposit date: | 2020-04-09 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4, 2021
|
|
4QXG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qxg by Molmil](/molmil-images/mine/4qxg) | |
6WMH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wmh by Molmil](/molmil-images/mine/6wmh) | |
6WNA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wna by Molmil](/molmil-images/mine/6wna) | Next generation monomeric IgG4 Fc | Descriptor: | Beta-2-microglobulin, IgG receptor FcRn large subunit p51, Immunoglobulin heavy constant gamma 4, ... | Authors: | Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F. | Deposit date: | 2020-04-22 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4, 2021
|
|