6SGY
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6SGW
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![BU of 6sgw by Molmil](/molmil-images/mine/6sgw) | Structure of the ESX-3 core complex | Descriptor: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | Authors: | Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. | Deposit date: | 2019-08-05 | Release date: | 2019-10-09 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
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5Y7Z
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![BU of 5y7z by Molmil](/molmil-images/mine/5y7z) | Complex structure of cyclin G-associated kinase with gefitinib | Descriptor: | Cyclin-G-associated kinase, Gefitinib, NANOBODY, ... | Authors: | Ohbayashi, N, Murayama, K, Kato-Murayama, M, Shirouzu, M. | Deposit date: | 2017-08-18 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib. ChemistryOpen, 7, 2018
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6SGZ
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![BU of 6sgz by Molmil](/molmil-images/mine/6sgz) | Structure of protomer 2 of the ESX-3 core complex | Descriptor: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | Authors: | Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. | Deposit date: | 2019-08-05 | Release date: | 2019-10-09 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
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5W8M
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![BU of 5w8m by Molmil](/molmil-images/mine/5w8m) | Crystal structure of Chaetomium thermophilum Vps29 | Descriptor: | GLYCEROL, TRIETHYLENE GLYCOL, Vacuolar protein sorting-associated protein 29 | Authors: | Collins, B.M, Leneva, N. | Deposit date: | 2017-06-21 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561, 2018
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7JRJ
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![BU of 7jrj by Molmil](/molmil-images/mine/7jrj) | Chlamydomonas reinhardtii radial spoke head and neck (recombinant) | Descriptor: | Flagellar radial spoke protein 1, Flagellar radial spoke protein 10, Flagellar radial spoke protein 2, ... | Authors: | Grossman-Haham, I, Coudray, N, Yu, Z, Wang, F, Zhang, N, Bhabha, G, Vale, R.D. | Deposit date: | 2020-08-12 | Release date: | 2020-12-16 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating. Nat.Struct.Mol.Biol., 28, 2021
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5YJO
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6SWZ
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6SF7
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![BU of 6sf7 by Molmil](/molmil-images/mine/6sf7) | Atomic resolution structure of SplF protease from Staphylococcus aureus | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | Authors: | Golik, P, Stach, N, Karim, A, Dubin, G. | Deposit date: | 2019-08-01 | Release date: | 2021-03-03 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Determinants of Substrate Specificity of SplF Protease from Staphylococcus aureus . Int J Mol Sci, 22, 2021
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5Y6U
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5Y80
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![BU of 5y80 by Molmil](/molmil-images/mine/5y80) | Complex structure of cyclin G-associated kinase with gefitinib | Descriptor: | Cyclin-G-associated kinase, Gefitinib, NANOBODY | Authors: | Ohbayashi, N, Murayama, K, Kato-Murayama, M, Shirouzu, M. | Deposit date: | 2017-08-18 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib. ChemistryOpen, 7, 2018
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5YE5
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![BU of 5ye5 by Molmil](/molmil-images/mine/5ye5) | structure of endo-lysosomal TRPML1 channel inserting into nanodisc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, mammalian endo-lysosomal TRPML1 channel | Authors: | Yang, M, Gao, N. | Deposit date: | 2017-09-15 | Release date: | 2017-11-15 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism Protein Cell, 8, 2017
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5X02
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![BU of 5x02 by Molmil](/molmil-images/mine/5x02) | Crystal structure of the FLT3 kinase domain bound to the inhibitor FF-10101 | Descriptor: | N-[(2S)-1-[5-[2-[(4-cyanophenyl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxidanylidene-propan-2-yl]-4-(dimethylamino)-N-methyl-but-2-enamide, Receptor-type tyrosine-protein kinase FLT3, SULFATE ION | Authors: | Fujikawa, N, Hirano, D, Takasaki, M, Terada, D, Hagiwara, S, Park, S.-Y, Sugiyama, K. | Deposit date: | 2017-01-19 | Release date: | 2018-01-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells withFLT3mutations. Blood, 131, 2018
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5YDZ
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8IMZ
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![BU of 8imz by Molmil](/molmil-images/mine/8imz) | Cryo-EM structure of mouse Piezo1-MDFIC complex (composite map) | Descriptor: | MyoD family inhibitor domain-containing protein, Piezo-type mechanosensitive ion channel component 1 | Authors: | Zhou, Z, Ma, X, Lin, Y, Cheng, D, Bavi, N, Li, J.V, Sutton, D, Yao, M, Harvey, N, Corry, B, Zhang, Y, Cox, C.D. | Deposit date: | 2023-03-07 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381, 2023
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6SX4
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5XJA
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![BU of 5xja by Molmil](/molmil-images/mine/5xja) | The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-AlFx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF2C, ... | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | Deposit date: | 2017-04-30 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.43 Å) | Cite: | Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation Cell Rep, 20, 2017
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6BX8
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![BU of 6bx8 by Molmil](/molmil-images/mine/6bx8) | Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | Descriptor: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | Authors: | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | Deposit date: | 2017-12-18 | Release date: | 2019-02-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294, 2019
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5XJB
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![BU of 5xjb by Molmil](/molmil-images/mine/5xjb) | The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-BeFx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Kinesin-like protein KIF2C, ... | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | Deposit date: | 2017-04-30 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation Cell Rep, 20, 2017
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8U7Z
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![BU of 8u7z by Molmil](/molmil-images/mine/8u7z) | KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(CTD)/Gbeta1gamma2 | Descriptor: | BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U82
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![BU of 8u82 by Molmil](/molmil-images/mine/8u82) | KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U81
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![BU of 8u81 by Molmil](/molmil-images/mine/8u81) | KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U83
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![BU of 8u83 by Molmil](/molmil-images/mine/8u83) | KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.975 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U80
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![BU of 8u80 by Molmil](/molmil-images/mine/8u80) | KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD) | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3 | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8U84
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![BU of 8u84 by Molmil](/molmil-images/mine/8u84) | KCTD5/Cullin3/Gbeta1gamma2 Complex: State D From Composite RELION Multi-body Refinement Map | Descriptor: | BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G. | Deposit date: | 2023-09-15 | Release date: | 2023-10-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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