8WI7
 
 | | Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, bS1 and RafH. | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Kumar, N, Sharma, S, Kaushal, P.S. | | 登録日 | 2023-09-24 | | 公開日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH.
Nat Commun, 15, 2024
|
|
9EU5
 | | SSX structure of Autotaxin at room temperature | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | 著者 | Eymery, M.C, McCarthy, A.A, Foos, N, Basu, S. | | 登録日 | 2024-03-27 | | 公開日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry.
Iucrj, 2024
|
|
8WI8
 | | Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome, bS1 and RafH. | | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Kumar, N, Sharma, S, Kaushal, P.S. | | 登録日 | 2023-09-24 | | 公開日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH.
Nat Commun, 15, 2024
|
|
8WTQ
 | | HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6-oxo-6,7,10,11-tetrahydro-5H,9H,13H-12-oxa-5,8-diaza-benzocycloundecene-8-carbonyl]-piperidin-4-yl}-acetic acid | | 分子名称: | 2-[1-[[(10~{S})-13-chloranyl-2-(2,2-dimethylpropyl)-10-(2-methoxyphenyl)-3-oxidanylidene-9-oxa-2,5-diazabicyclo[9.4.0]pentadeca-1(15),11,13-trien-5-yl]carbonyl]piperidin-4-yl]ethanoic acid, PHOSPHATE ION, Squalene synthase | | 著者 | Suzuki, M, Haginoya, N, Suzuki, M, Ishigai, Y, Terayama, K, Kanda, A, Sugita, K. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors.
J.Med.Chem., 67, 2024
|
|
8YLB
 | | Cocrystal structures of agonists compound 1 with HsClpP | | 分子名称: | 5-[(2-methylphenyl)methyl]-11-(phenylmethyl)-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),6-dien-8-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | | 著者 | Zhao, N, Zhu, Y, Bao, R. | | 登録日 | 2024-03-06 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
J.Med.Chem., 67, 2024
|
|
8VCZ
 | |
8VD3
 | |
9BBM
 | |
8W8S
 | | Cryo-EM structure of the AA14-bound GPR101 complex | | 分子名称: | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Probable G-protein coupled receptor 101 | | 著者 | Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. | | 登録日 | 2023-09-04 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 20, 2024
|
|
8W8R
 | | Cryo-EM structure of the AA-14-bound GPR101-Gs complex | | 分子名称: | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. | | 登録日 | 2023-09-04 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 20, 2024
|
|
8XI6
 | | SARS-CoV-2 Omicron BQ.1.1 Variant Spike Protein Complexed with MO11 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ishimaru, H, Nishimura, M, Shigematsu, H, Marini, M.I, Hasegawa, N, Takamiya, R, Iwata, S, Mori, Y. | | 登録日 | 2023-12-19 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Epitopes of an antibody that neutralizes a wide range of SARS-CoV-2 variants in a conserved subdomain 1 of the spike protein.
J.Virol., 98, 2024
|
|
8WLS
 | |
8XMN
 | | Voltage-gated sodium channel Nav1.7 variant M2 | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Li, Z, Wu, Q, Huang, G. | | 登録日 | 2023-12-27 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Dissection of the structure-function relationship of Na v channels.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8WMS
 | |
9ENT
 | | SSX structure of Autotaxin in cryogenic conditions | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | 著者 | Eymery, M.C, McCarthy, A.A, Foos, N, Basu, S. | | 登録日 | 2024-03-13 | | 公開日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry.
Iucrj, 2024
|
|
9CLY
 | | Crystal structure of the 3-ketoacyl-(acyl-carrier-protein) reductase, CylG, from Streptococcus agalactiae 2603V/R | | 分子名称: | CylG protein, IMIDAZOLE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Maltseva, N, Kim, Y, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2024-07-12 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Crystal structure of the 3-ketoacyl-(acyl-carrier-protein) reductase, CylG, from Streptococcus agalactiae 2603V/R
To be published
|
|
8VVA
 | |
8VD1
 | | Crystal Structure of KAI2 from Oryza sativa with MPD | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Probable esterase D14L | | 著者 | Gilio, A.K, Shabek, N, Guercio, A.M, Pawlak, J. | | 登録日 | 2023-12-14 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction.
J.Biol.Chem., 300, 2024
|
|
9EME
 | | AL amyloid fibril from the FOR103 light chain | | 分子名称: | lambda 3 immunoglobulin light chain fragment, residues 2-116 | | 著者 | Pfeiffer, P.B, Karimi-Farsijani, S, Kupfer, N, Schmidt, M, Faendrich, M. | | 登録日 | 2024-03-08 | | 公開日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis.
Nat Commun, 15, 2024
|
|
8WX0
 | | PNPase of M.tuberculosis with its RNA substrate | | 分子名称: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase, RNA (24-mer) | | 著者 | Wang, N, Sheng, Y.N. | | 登録日 | 2023-10-27 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation.
Arch.Biochem.Biophys., 754, 2024
|
|
9FBF
 | | VDR complex with UG-481 | | 分子名称: | (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{S})-5-methyl-1-[(1~{R},2~{R})-2-(3-methyl-3-oxidanyl-butyl)cyclopropyl]-5-oxidanyl-hexyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | 著者 | Rochel, N. | | 登録日 | 2024-05-13 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain.
J.Med.Chem., 67, 2024
|
|
9AYJ
 | | Cryo-EM structure of human Cav3.2 with TTA-P2 | | 分子名称: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-[(1-{[(4S)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide, ... | | 著者 | Fan, X, Huang, J, Yan, N. | | 登録日 | 2024-03-07 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for human Ca v 3.2 inhibition by selective antagonists.
Cell Res., 34, 2024
|
|
9EYR
 | | VDR complex with gemini analog UG-480 | | 分子名称: | (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{R})-5-methyl-1-[(1~{S},2~{S})-2-(3-methyl-3-oxidanyl-butyl)cyclopropyl]-5-oxidanyl-hexyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | 著者 | Rochel, N. | | 登録日 | 2024-04-09 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain.
J.Med.Chem., 67, 2024
|
|
8VLX
 | |
8W35
 | | Aca2 from Pectobacterium phage ZF40 bound to RNA | | 分子名称: | Anti-CRISPR associated (Aca) protein, Aca2, IR2 and IR-RBS RNA | | 著者 | Wilkinson, M.E, Birkholz, N, Kimanius, D, Fineran, P.C. | | 登録日 | 2024-02-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein.
Nature, 631, 2024
|
|
