6F76
| Antibody derived (Abd-8) small molecule binding to KRAS. | 分子名称: | 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline, GTPase KRas, MAGNESIUM ION, ... | 著者 | Bery, N, Cruz-Migoni, A, Quevedo, C.E, Phillips, S.V.E, Carr, S, Rabbitts, T.H. | 登録日 | 2017-12-07 | 公開日 | 2018-08-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife, 7, 2018
|
|
4Y02
| Crystal structure of dipeptidyl peptidase 11 (DPP11) from Porphyromonas gingivalis (Ground) | 分子名称: | GLYCEROL, POTASSIUM ION, Peptidase S46 | 著者 | Sakamoto, Y, Suzuki, Y, Iizuka, I, Tateoka, C, Roppongi, S, Fujimoto, M, Nonaka, T, Ogasawara, W, Tanaka, N. | 登録日 | 2015-02-05 | 公開日 | 2015-07-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity. Sci Rep, 5, 2015
|
|
6F7Q
| Human Butyrylcholinesterase complexed with N-Propargyliperidines | 分子名称: | 1,2-ETHANEDIOL, 2-[[(3~{R})-1-(2,3-dihydro-1~{H}-inden-2-yl)piperidin-3-yl]methyl-(8-oxidanylquinolin-2-yl)carbonyl-amino]ethyl-dimethyl-azanium, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Coquelle, N, Knez, D, Colletier, J.P, Gobec, S. | 登録日 | 2017-12-11 | 公開日 | 2018-09-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. Eur.J.Med.Chem., 156, 2018
|
|
4Y28
| The structure of plant photosystem I super-complex at 2.8 angstrom resolution. | 分子名称: | (1R,2S)-4-{(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl}-2,5,5-trimethylcyclohex-3-en-1-ol, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Mazor, Y, Brovikov, A, Nelson, N. | 登録日 | 2015-02-09 | 公開日 | 2015-08-19 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The structure of plant photosystem I super-complex at 2.8 angstrom resolution. Elife, 4, 2015
|
|
7PI5
| Unstacked stretched Dunaliella PSII | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Caspy, I, Fadeeva, M, Mazor, Y, Nelson, N. | 登録日 | 2021-08-19 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Structure of Dunaliella Photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes. Elife, 12, 2023
|
|
7PI0
| Unstacked compact Dunaliella PSII | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Caspy, I, Fadeeva, M, Mazor, Y, Nelson, N. | 登録日 | 2021-08-19 | 公開日 | 2022-08-17 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Structure of Dunaliella Photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes. Elife, 12, 2023
|
|
8J72
| Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1 | 分子名称: | E3 ubiquitin-protein ligase TRIM71, lncRNA Trincr1 | 著者 | Shi, F.D, Zhang, K, Che, S.Y, Zhi, S.X, Yang, N. | 登録日 | 2023-04-27 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein. Sci Bull (Beijing), 69, 2024
|
|
1WYC
| Structure of 6-aminohexanoate-dimer hydrolase, DN mutant | 分子名称: | 6-aminohexanoate-dimer hydrolase | 著者 | Negoro, S, Ohki, T, Shibata, N, Mizuno, N, Wakitani, Y, Tsurukame, J, Matsumoto, K, Kawamoto, I, Takeo, M, Higuchi, Y. | 登録日 | 2005-02-09 | 公開日 | 2006-02-21 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Nylon-oligomer degrading enzyme/substrate complex: catalytic mechanism of 6-aminohexanoate-dimer hydrolase J.Mol.Biol., 370, 2007
|
|
7PNK
| Unstacked compact Dunaliella PSII | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Caspy, I, Fadeeva, M, Mazor, Y, Nelson, N. | 登録日 | 2021-09-07 | 公開日 | 2022-08-17 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Structure of Dunaliella Photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes. Elife, 12, 2023
|
|
4XU6
| Crystal structure of cross-linked MvINS R77C trimer at 1.9A resolution | 分子名称: | N-TRIDECANOIC ACID, Uncharacterized protein, octyl beta-D-glucopyranoside | 著者 | Ren, R.B, Wu, J.P, Yan, C.Y, He, Y, Yan, N. | 登録日 | 2015-01-25 | 公開日 | 2015-10-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels Science, 349, 2015
|
|
6F8E
| PH domain from TgAPH | 分子名称: | Pleckstrin homology domain | 著者 | Darvill, N, Liu, B, Matthews, S, Soldati-Favre, D, Rouse, S, Benjamin, S, Blake, T, Dubois, D.J, Hammoudi, P.M, Pino, P. | 登録日 | 2017-12-13 | 公開日 | 2019-01-30 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites. Structure, 26, 2018
|
|
7PIN
| Stacked compact Dunaliella PSII | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Caspy, I, Fadeeva, M, Mazor, Y, Nelson, N. | 登録日 | 2021-08-22 | 公開日 | 2022-08-17 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of Dunaliella Photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes. Elife, 12, 2023
|
|
6FDE
| Crystal Structure of the HHD2 Domain of Whirlin : 3-helix conformation | 分子名称: | Whirlin | 著者 | Delhommel, F, Cordier, F, Saul, F, Haouz, A, Wolff, N. | 登録日 | 2017-12-22 | 公開日 | 2018-08-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural plasticity of the HHD2 domain of whirlin. FEBS J., 285, 2018
|
|
6FIS
| |
7PIW
| Stacked stretched Dunaliella PSII | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Caspy, I, Fadeeva, M, Mazor, Y, Nelson, N. | 登録日 | 2021-08-23 | 公開日 | 2022-08-17 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of Dunaliella Photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes. Elife, 12, 2023
|
|
8SCD
| Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate | 分子名称: | 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, CHLORIDE ION, ... | 著者 | Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2023-04-05 | 公開日 | 2023-05-03 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
|
|
6FIW
| |
6F2Y
| Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) in complex with Ap4A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ... | 著者 | Dohler, C, Zebisch, M, Strater, N. | 登録日 | 2017-11-27 | 公開日 | 2018-08-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3). Sci Rep, 8, 2018
|
|
6F4J
| Crystal structure of Drosophila melanogaster SNF/U2A' complex | 分子名称: | POLYETHYLENE GLYCOL (N=34), Probable U2 small nuclear ribonucleoprotein A', SULFATE ION, ... | 著者 | Weber, G, DeKoster, G, Holton, N, Hall, K.B, Wahl, M.C. | 登録日 | 2017-11-29 | 公開日 | 2018-06-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Molecular principles underlying dual RNA specificity in the Drosophila SNF protein. Nat Commun, 9, 2018
|
|
7PKU
| Structure of SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a | 分子名称: | 3C-like proteinase, Nucleoprotein | 著者 | Bessa, L.M, Guseva, S, Camacho-Zarco, A.R, Salvi, N, Blackledge, M. | 登録日 | 2021-08-26 | 公開日 | 2022-01-19 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a. Sci Adv, 8, 2022
|
|
8SBR
| |
8J9F
| Structure of STG-hydrolyzing beta-glucosidase 1 (PSTG1) | 分子名称: | Beta-glucosidase, GLYCEROL | 著者 | Yanai, T, Imaizumi, R, Takahashi, Y, Katsumura, E, Yamamoto, M, Nakayama, T, Yamashita, S, Takeshita, K, Sakai, N, Matsuura, H. | 登録日 | 2023-05-03 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural insights into a bacterial beta-glucosidase capable of degrading sesaminol triglucoside to produce sesaminol: toward the understanding of the aglycone recognition mechanism by the C-terminal lid domain. J.Biochem., 174, 2023
|
|
8SPJ
| |
4Y9X
| Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis in complex with Mn2+, uridine-diphosphate-glucose (UDP-Glc) and phosphoglyceric acid (PGA) - GpgS Mn2+ UDP-Glc PGA-3 | 分子名称: | 1,2-ETHANEDIOL, 3-PHOSPHOGLYCERIC ACID, CHLORIDE ION, ... | 著者 | Albesa-Jove, D, Rodrigo-Unzueta, A, Cifuente, J.O, Urresti, S, Comino, N, Sancho-Vaello, E, Guerin, M.E. | 登録日 | 2015-02-17 | 公開日 | 2015-07-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.637 Å) | 主引用文献 | A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase. Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
6EXZ
| Crystal structure of Mex67 C-term | 分子名称: | FORMIC ACID, mRNA export factor MEX67 | 著者 | Mohamad, N, Bravo, J. | 登録日 | 2017-11-10 | 公開日 | 2018-11-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs. Embo Rep., 2019
|
|