6F76
Antibody derived (Abd-8) small molecule binding to KRAS.
Summary for 6F76
Entry DOI | 10.2210/pdb6f76/pdb |
Descriptor | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total) |
Functional Keywords | abd-8, inhibitor, kras, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 122952.16 |
Authors | Bery, N.,Cruz-Migoni, A.,Quevedo, C.E.,Phillips, S.V.E.,Carr, S.,Rabbitts, T.H. (deposition date: 2017-12-07, release date: 2018-08-08) |
Primary citation | Bery, N.,Cruz-Migoni, A.,Bataille, C.J.,Quevedo, C.E.,Tulmin, H.,Miller, A.,Russell, A.,Phillips, S.E.,Carr, S.B.,Rabbitts, T.H. BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife, 7:-, 2018 Cited by PubMed: 29989546DOI: 10.7554/eLife.37122 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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