6F76
Antibody derived (Abd-8) small molecule binding to KRAS.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (B, A, C, D, E...) | GTPase KRas | polymer | 173 | 19685.2 | 6 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | G, J, M, Q, R... (B, A, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 3 | H, K, N, P, S... (B, A, C, D, E...) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 6 | Chemie (GNP) | |||
| 4 | I, L, O, V (B, A, C, F) | 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline | non-polymer | 390.5 | 4 | Chemie (CVK) | |||
| 5 | AA, BA, W, X, Y... (E, F, B, A, C...) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
B, A, C, D, E, F: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Ala -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| His 61 | Gln 61 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 118111.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4840.9 | |
| All* | Total formula weight | 122952.2 |
