6F7Q

Human Butyrylcholinesterase complexed with N-Propargyliperidines

Summary for 6F7Q

• Entry DOI: 10.2210/pdb6f7q/pdb
• Descriptor: Cholinesterase, SULFATE ION, CHLORIDE ION, ... (12 entities in total)
• Functional Keywords: alzheimer disease ad butyrylcholinesterase n-propargyliperidines, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 126208.40

Authors

Coquelle, N.,Knez, D.,Colletier, J.P.,Gobec, S. (deposition date: 2017-12-11, release date: 2018-09-05, Last modification date: 2020-07-29)

• Primary citation: Knez, D.,Coquelle, N.,Pislar, A.,Zakelj, S.,Jukic, M.,Sova, M.,Mravljak, J.,Nachon, F.,Brazzolotto, X.,Kos, J.,Colletier, J.P.,Gobec, S.; Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.; Eur.J.Med.Chem., 156:598-617, 2018; PubMed: 30031971; DOI: 10.1016/j.ejmech.2018.07.033

Experimental method

X-RAY DIFFRACTION (2.6 Å)