8SBR

E coli. CTP synthase in complex with CTP (sodium malonate + 20 mM MgCl2)

Summary for 8SBR

Entry DOI	10.2210/pdb8sbr/pdb
Descriptor	CTP synthase, MALONIC ACID, CYTIDINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	inhibitor complex, metabolic enzyme, cytosolic protein, ligase, ligase-product complex, ligase/product
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	122068.39
Authors	Holyoak, T.,McLeod, M.J.,Tran, N. (deposition date: 2023-04-04, release date: 2023-05-24, Last modification date: 2023-06-07)
Primary citation	McLeod, M.J.,Tran, N.,McCluskey, G.D.,Gillis, T.D.,Bearne, S.L.,Holyoak, T. A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein Sci., 32:e4648-e4648, 2023 Cited by PubMed: 37106216 DOI: 10.1002/pro.4648 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation