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PDB: 56 results
3BK3
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BU of 3bk3 by Molmil
Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2
Descriptor: Bone morphogenetic protein 2, Crossveinless 2
Authors:Mueller, T.D, Sebald, W, Zhang, J.-L.
Deposit date:2007-12-05
Release date:2008-05-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
Dev.Cell, 14, 2008
1WAQ
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BU of 1waq by Molmil
Crystal structure of human Growth and Differentiation Factor 5 (GDF-5)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GROWTH/DIFFERENTIATION FACTOR 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2004-10-27
Release date:2005-05-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib.
J.Mol.Biol., 349, 2005
5DR5
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BU of 5dr5 by Molmil
Crystal structure of the sclerostin-neutralizing Fab AbD09097
Descriptor: AbD09097 Fab heavy chain, AbD09097 Fab light chain
Authors:Mueller, T.D, Boschert, V, Weidauer, S.E, Muth, E.M, Knappik, A, Frisch, C.
Deposit date:2015-09-15
Release date:2016-08-31
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Generation and Affinity Maturation of Neutralizing Anti-Sclerostin Antibodies
to be published
3NH7
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BU of 3nh7 by Molmil
Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA
Descriptor: Antibody fragment Fab AbD1556, heavy chain, light chain, ...
Authors:Mueller, T.D, Harth, S, Sebald, W.
Deposit date:2010-06-14
Release date:2010-10-27
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Plos One, 5, 2010
1IFY
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BU of 1ify by Molmil
Solution Structure of the Internal UBA Domain of HHR23A
Descriptor: UV EXCISION REPAIR PROTEIN RAD23 HOMOLOG A
Authors:Mueller, T.D, Feigon, J.
Deposit date:2001-04-13
Release date:2002-07-03
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.
J.Mol.Biol., 319, 2002
3QB4
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BU of 3qb4 by Molmil
Crystal structure of a TGF-beta ligand-receptor complex
Descriptor: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2011-01-12
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:GDF-5 can act as a context-dependent BMP-2 antagonist.
Bmc Biol., 13, 2015
6H41
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BU of 6h41 by Molmil
Structure of the complex of the IL-5 inhibitory peptide AF17121 bound to the IL-5 receptor IL-5Ralpha
Descriptor: Interleukin-5 receptor subunit alpha, VAL-ASP-GLU-CYS-TRP-ARG-ILE-ILE-ALA-SER-HIS-THR-TRP-PHE-CYS-ALA-GLU-GLU
Authors:Mueller, T.D, Scheide, J.P.
Deposit date:2018-07-20
Release date:2018-12-26
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.
J. Mol. Biol., 431, 2019
1P98
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BU of 1p98 by Molmil
High-resolution NMR structure of the Ubl-domain of HHR23A
Descriptor: UV excision repair protein RAD23 homolog A
Authors:Mueller, T.D, Feigon, J.
Deposit date:2003-05-09
Release date:2003-10-07
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural determinants for the binding of ubiquitin-like domains to the proteasome.
Embo J., 22, 2003
1RAX
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BU of 1rax by Molmil
RA-DOMAIN OF RAL GUANOSINE-NUCLEOTIDE DISSOCIATION STIMULATOR
Descriptor: PROTEIN (RA-DOMAIN OF RAL GUANOSINE DISSOCIATION STIMULATOR)
Authors:Mueller, T.D, Handel, L, Schmieder, P, Oschkinat, H.
Deposit date:1999-03-13
Release date:1999-03-19
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:High-Resolution Structure of the Ra-Domain of Human Ralgds and a Dynamics Study of its Binding Loop to Ras
To be Published
3QT2
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BU of 3qt2 by Molmil
Structure of a cytokine ligand-receptor complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Interleukin-5, Interleukin-5 receptor subunit alpha, ...
Authors:Mueller, T.D, Patino, E, Kotzsch, A, Saremba, S, Nickel, J, Schmitz, W, Sebald, W.
Deposit date:2011-02-22
Release date:2012-02-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha.
Structure, 19, 2011
3B5K
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BU of 3b5k by Molmil
Crystal structure of murine interleukin-5
Descriptor: Interleukin-5
Authors:Mueller, T.D, Patino, E.
Deposit date:2007-10-26
Release date:2008-11-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of murine interleukin-5
To be Published
1HIK
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BU of 1hik by Molmil
INTERLEUKIN-4 (WILD-TYPE)
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Buehner, M.
Deposit date:1995-06-01
Release date:1996-01-29
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
2H64
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BU of 2h64 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D, Sebald, W, Weber, D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
1P9C
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BU of 1p9c by Molmil
NMR solution structure of the C-terminal ubiquitin-interacting motif of the proteasome subunit S5a
Descriptor: 26S proteasome non-ATPase regulatory subunit 4
Authors:Mueller, T.D, Feigon, J.
Deposit date:2003-05-10
Release date:2003-10-07
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural determinants for the binding of ubiquitin-like domains to the proteasome.
Embo J., 22, 2003
1P9D
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BU of 1p9d by Molmil
High-resolution structure of the complex of HHR23A ubiquitin-like domain and the C-terminal ubiquitin-interacting motif of proteasome subunit S5a
Descriptor: 26S proteasome non-ATPase regulatory subunit 4, UV excision repair protein RAD23 homolog A
Authors:Mueller, T.D, Feigon, J.
Deposit date:2003-05-10
Release date:2003-10-07
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural determinants for the binding of ubiquitin-like domains to the proteasome.
Embo J., 22, 2003
1HIJ
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BU of 1hij by Molmil
INTERLEUKIN-4 MUTANT WITH ARG 88 REPLACED WITH GLN (R88Q)
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Buehner, M.
Deposit date:1995-06-01
Release date:1996-01-29
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
2H62
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BU of 2h62 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
2MBK
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BU of 2mbk by Molmil
The Clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed
Descriptor: Crossveinless 2
Authors:Mueller, T.D, Fiebig, J.E, Weidauer, S.E, Qiu, L, Bauer, M, Schmieder, P, Beerbaum, M, Zhang, J, Oschkinat, H, Sebald, W.
Deposit date:2013-08-02
Release date:2013-10-16
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed.
Molecules, 18, 2013
2R52
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BU of 2r52 by Molmil
Crystal structure analysis of Bone Morphogenetic Protein-6 (BMP-6)
Descriptor: Bone morphogenetic protein 6, ISOPROPYL ALCOHOL
Authors:Mueller, T.D, Sebald, W, Saremba, S.
Deposit date:2007-09-03
Release date:2008-01-15
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
Febs J., 275, 2007
2R53
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BU of 2r53 by Molmil
Crystal structure analysis of Bone Morphogenetic Protein-6 variant B2 (B2-BMP-6)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Bone morphogenetic protein 6
Authors:Mueller, T.D, Sebald, W.
Deposit date:2007-09-03
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
Febs J., 275, 2007
2CYK
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BU of 2cyk by Molmil
ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Sebald, W, Oschkinat, H.
Deposit date:1994-08-16
Release date:1994-12-20
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994
1CYL
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BU of 1cyl by Molmil
ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Descriptor: INTERLEUKIN-4
Authors:Mueller, T, Sebald, W, Oschkinat, H.
Deposit date:1994-02-21
Release date:1994-09-30
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994
2B8X
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BU of 2b8x by Molmil
Crystal structure of the interleukin-4 variant F82D
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8Z
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BU of 2b8z by Molmil
Crystal structure of the interleukin-4 variant R85A
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-10
Release date:2006-05-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2D48
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BU of 2d48 by Molmil
Crystal structure of the Interleukin-4 variant T13D
Descriptor: Interleukin-4, SULFATE ION
Authors:Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
Deposit date:2005-10-11
Release date:2006-05-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006

 

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