6H41

Structure of the complex of the IL-5 inhibitory peptide AF17121 bound to the IL-5 receptor IL-5Ralpha

Summary for 6H41

• Entry DOI: 10.2210/pdb6h41/pdb
• Related: 3QT2
• Descriptor: Interleukin-5 receptor subunit alpha, VAL-ASP-GLU-CYS-TRP-ARG-ILE-ILE-ALA-SER-HIS-THR-TRP-PHE-CYS-ALA-GLU-GLU (3 entities in total)
• Functional Keywords: interleukin-5, inhibitor peptide, peptide-receptor complex, atopic diseases, cytokine
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 37390.08

Authors

Mueller, T.D.,Scheide, J.P. (deposition date: 2018-07-20, release date: 2018-12-26, Last modification date: 2019-02-27)

• Primary citation: Scheide-Noeth, J.P.,Rosen, M.,Baumstark, D.,Dietz, H.,Mueller, T.D.; Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.; J. Mol. Biol., 431:714-731, 2019; PubMed: 30529748; DOI: 10.1016/j.jmb.2018.11.029

Experimental method

X-RAY DIFFRACTION (2.75 Å)