7A4A
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3NSW
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![BU of 3nsw by Molmil](/molmil-images/mine/3nsw) | Crystal Structure of Ancylostoma ceylanicum Excretory-Secretory Protein 2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Excretory-secretory protein 2 | Authors: | Kucera, K, Modis, Y. | Deposit date: | 2010-07-02 | Release date: | 2011-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Ancylostoma ceylanicum Excretory-Secretory Protein 2 Adopts a Netrin-Like Fold and Defines a Novel Family of Nematode Proteins. J.Mol.Biol., 408, 2011
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3NEC
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![BU of 3nec by Molmil](/molmil-images/mine/3nec) | Crystal Structure of Toxoplasma gondii Profilin | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Inflammatory profilin, SULFATE ION | Authors: | Kucera, K, Modis, Y. | Deposit date: | 2010-06-08 | Release date: | 2010-09-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. J.Mol.Biol., 403, 2010
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7NIC
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![BU of 7nic by Molmil](/molmil-images/mine/7nic) | |
7NGA
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![BU of 7nga by Molmil](/molmil-images/mine/7nga) | |
7NIQ
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![BU of 7niq by Molmil](/molmil-images/mine/7niq) | |
6T1B
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![BU of 6t1b by Molmil](/molmil-images/mine/6t1b) | |
6T0Y
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6TL1
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![BU of 6tl1 by Molmil](/molmil-images/mine/6tl1) | Crystal structure of the TASOR pseudo-PARP domain | Descriptor: | GLYCEROL, Protein TASOR | Authors: | Douse, C.H, Timms, R.T, Freund, S.M.V, Modis, Y. | Deposit date: | 2019-11-29 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control. Nat Commun, 11, 2020
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8P0C
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![BU of 8p0c by Molmil](/molmil-images/mine/8p0c) | Rubella virus p150 macro domain (apo) | Descriptor: | Non-structural polyprotein p200 | Authors: | Stoll, G.A, Modis, Y. | Deposit date: | 2023-05-10 | Release date: | 2024-01-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structure and biochemical activity of the macrodomain from rubella virus p150. J.Virol., 98, 2024
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8P0E
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1RH5
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![BU of 1rh5 by Molmil](/molmil-images/mine/1rh5) | The structure of a protein conducting channel | Descriptor: | Preprotein translocase secE subunit, Preprotein translocase secY subunit, SecBeta | Authors: | van den Berg, B, Clemons Jr, W.M, Collinson, I, Modis, Y, Hartmann, E, Harrison, S.C, Rapoport, T.A. | Deposit date: | 2003-11-13 | Release date: | 2004-01-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray structure of a protein-conducting channel Nature, 427, 2004
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1RHZ
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![BU of 1rhz by Molmil](/molmil-images/mine/1rhz) | The structure of a protein conducting channel | Descriptor: | Preprotein translocase secE subunit, Preprotein translocase secY subunit, SecBeta | Authors: | van den Berg, B, Clemons Jr, W.M, Collinson, I, Modis, Y, Hartmann, E, Harrison, S.C, Rapoport, T.A. | Deposit date: | 2003-11-15 | Release date: | 2004-01-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | X-ray structure of a protein-conducting channel. Nature, 427, 2004
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7BKQ
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![BU of 7bkq by Molmil](/molmil-images/mine/7bkq) | CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Isoform 2 of Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), ... | Authors: | Yu, Q, Modis, Y. | Deposit date: | 2021-01-17 | Release date: | 2021-11-17 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
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7BKP
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![BU of 7bkp by Molmil](/molmil-images/mine/7bkp) | CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | Authors: | Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y. | Deposit date: | 2021-01-16 | Release date: | 2021-11-17 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
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4JNT
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6G1X
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![BU of 6g1x by Molmil](/molmil-images/mine/6g1x) | CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-22 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6G1S
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![BU of 6g1s by Molmil](/molmil-images/mine/6g1s) | CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-21 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GKM
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![BU of 6gkm by Molmil](/molmil-images/mine/6gkm) | CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-21 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6H61
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![BU of 6h61 by Molmil](/molmil-images/mine/6h61) | CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-07-25 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.02 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GJZ
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![BU of 6gjz by Molmil](/molmil-images/mine/6gjz) | CryoEM structure of the MDA5-dsRNA filament in complex with AMPPNP | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-17 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6GKH
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![BU of 6gkh by Molmil](/molmil-images/mine/6gkh) | CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-05-21 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6G19
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![BU of 6g19 by Molmil](/molmil-images/mine/6g19) | CryoEM structure of the MDA5-dsRNA filament with 74-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-20 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6H66
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![BU of 6h66 by Molmil](/molmil-images/mine/6h66) | CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-07-26 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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4DQ7
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![BU of 4dq7 by Molmil](/molmil-images/mine/4dq7) | |