9F3P

Cryo-EM structure of the A946T MDA5-dsRNA filament

Summary for 9F3P

• Entry DOI: 10.2210/pdb9f3p/pdb
• Related: 9F0J 9F1U 9F20 9F2L 9F2W
• EMDB information: 50111 50136 50137 50150 50165 50175
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3'), RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3'), ... (4 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 126368.32

Authors

Singh, R.,Herrero del Valle, A.,Modis, Y. (deposition date: 2024-04-25, release date: 2025-02-26)

• Primary citation: Singh, R.,Herrero del Valle, A.,Joiner, J.D.,Zwaagstra, M.,Ferguson, B.J.,van Kuppeveld, F.J.M.,Modis, Y.; Molecular basis of autoimmune disease protection by MDA5 variants; Biorxiv, 2024; DOI: 10.1101/2024.10.03.616466

Experimental method

ELECTRON MICROSCOPY (3.97 Å)