6TL1
Crystal structure of the TASOR pseudo-PARP domain
Summary for 6TL1
| Entry DOI | 10.2210/pdb6tl1/pdb |
| Descriptor | Protein TASOR, GLYCEROL (3 entities in total) |
| Functional Keywords | nuclear protein; transcriptional repressor; epigenetic silencing; histone h3 lysine 9 methylation (h3k9me3); transposable element; line1 element; rna-binding protein, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 49736.95 |
| Authors | Douse, C.H.,Timms, R.T.,Freund, S.M.V.,Modis, Y. (deposition date: 2019-11-29, release date: 2020-09-16, Last modification date: 2020-10-14) |
| Primary citation | Douse, C.H.,Tchasovnikarova, I.A.,Timms, R.T.,Protasio, A.V.,Seczynska, M.,Prigozhin, D.M.,Albecka, A.,Wagstaff, J.,Williamson, J.C.,Freund, S.M.V.,Lehner, P.J.,Modis, Y. TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control. Nat Commun, 11:4940-4940, 2020 Cited by PubMed: 33009411DOI: 10.1038/s41467-020-18761-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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