9F1U

Cryo-EM structure of the I923V MDA5-dsRNA filament with ADP-AlF4 bound and 81-degree helical twist

Summary for 9F1U

• Entry DOI: 10.2210/pdb9f1u/pdb
• Related: 9F0J
• EMDB information: 50111 50136
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3'), RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3'), ... (6 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 126204.06

Authors

Singh, R.,Herrero del Valle, A.,Modis, Y. (deposition date: 2024-04-20, release date: 2025-02-26)

• Primary citation: Singh, R.,Herrero del Valle, A.,Joiner, J.D.,Zwaagstra, M.,Ferguson, B.J.,van Kuppeveld, F.J.M.,Modis, Y.; Molecular basis of autoimmune disease protection by MDA5 variants; Biorxiv, 2024; DOI: 10.1101/2024.10.03.616466

Experimental method

ELECTRON MICROSCOPY (3.67 Å)