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PDB: 51 件
8SX4
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BU of 8sx4 by Molmil
Crystal Structure of eIF4e in complex with Compound 7n
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E, [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid
著者Meagher, J.L, Stuckey, J.A.
登録日2023-05-19
公開日2023-06-21
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.986 Å)
主引用文献Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
J.Med.Chem., 66, 2023
2VSL
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BU of 2vsl by Molmil
Crystal Structure of XIAP BIR3 with a Bivalent Smac Mimetic
分子名称: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, PEPTIDE (MAA-LYS-PRO-PHE), POLYETHYLENE GLYCOL (N=34), ...
著者Meagher, J.L, Stuckey, J.A.
登録日2008-04-24
公開日2008-09-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein.
Biochemistry, 47, 2008
6UEJ
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BU of 6uej by Molmil
Crystal structure of human zinc finger antiviral protein bound to RNA
分子名称: RNA (5'-R(P*UP*CP*G)-3'), SPERMINE, ZINC ION, ...
著者Meagher, J.L, Smith, J.L.
登録日2019-09-21
公開日2019-11-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Proc.Natl.Acad.Sci.USA, 116, 2019
6UEI
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BU of 6uei by Molmil
Crystal structure of human zinc finger antiviral protein
分子名称: ZINC ION, Zinc finger CCCH-type antiviral protein 1
著者Meagher, J.L, Smith, J.L.
登録日2019-09-21
公開日2019-11-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Proc.Natl.Acad.Sci.USA, 116, 2019
7KMV
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BU of 7kmv by Molmil
Structure of Malaysian Banana Lectin F84T
分子名称: Jacalin-type lectin domain-containing protein, SULFATE ION
著者Meagher, J.L, Stuckey, J.A.
登録日2020-11-03
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Sci Rep, 11, 2021
7KMU
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BU of 7kmu by Molmil
Structure of WT Malaysian Banana Lectin
分子名称: 1,2-ETHANEDIOL, Jacalin-type lectin domain-containing protein
著者Meagher, J.L, Stuckey, J.A.
登録日2020-11-03
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Sci Rep, 11, 2021
6NJS
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BU of 6njs by Molmil
Stat3 Core in complex with compound SD36
分子名称: Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name)
著者Meagher, J.L, Stuckey, J.A.
登録日2019-01-04
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36, 2019
6NUQ
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BU of 6nuq by Molmil
Stat3 Core in complex with compound SI109
分子名称: Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name)
著者Meagher, J.L, Stuckey, J.A.
登録日2019-02-01
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36, 2019
2BN0
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BU of 2bn0 by Molmil
Banana Lectin bound to Laminaribiose
分子名称: CADMIUM ION, RIPENING-ASSOCIATED PROTEIN, SULFATE ION, ...
著者Meagher, J.L, Winter, H.C, Ezell, P, Goldstein, I.J, Stuckey, J.A.
登録日2005-03-17
公開日2005-06-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Banana Lectin Reveals a Novel Second Sugar Binding Site.
Glycobiology, 15, 2005
2BMZ
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BU of 2bmz by Molmil
Banana Lectin bound to Xyl-b1,3 Man-a-O-Methyl (XM)
分子名称: CADMIUM ION, RIPENING-ASSOCIATED PROTEIN, SULFATE ION, ...
著者Meagher, J.L, Winter, H.C, Ezell, P, Goldstein, I.J, Stuckey, J.A.
登録日2005-03-17
公開日2005-06-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Banana Lectin Reveals a Novel Second Sugar Binding Site.
Glycobiology, 15, 2005
2BMY
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BU of 2bmy by Molmil
Banana Lectin
分子名称: CADMIUM ION, RIPENING-ASSOCIATED PROTEIN, SULFATE ION
著者Meagher, J.L, Winter, H.C, Ezell, P, Goldstein, I.J, Stuckey, J.A.
登録日2005-03-17
公開日2005-06-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Banana Lectin Reveals a Novel Second Sugar Binding Site.
Glycobiology, 15, 2005
5TRF
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BU of 5trf by Molmil
MDM2 in complex with SAR405838
分子名称: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ...
著者Meagher, J.L, Stuckey, J.A.
登録日2016-10-26
公開日2016-11-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
Cancer Res., 74, 2014
5UOO
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BU of 5uoo by Molmil
BRD4 bromodomain 2 in complex with CD161
分子名称: 7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indole, Bromodomain-containing protein 4
著者Meagher, J.L, Stuckey, J.A.
登録日2017-02-01
公開日2017-05-17
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
J. Med. Chem., 60, 2017
5VTB
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BU of 5vtb by Molmil
Crystal structure of RBBP4 bound to BCL11a peptide
分子名称: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4
著者Meagher, J.L, Stuckey, J.A.
登録日2017-05-16
公開日2017-12-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
J. Biol. Chem., 293, 2018
4PIT
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BU of 4pit by Molmil
Crystal Structure of Banana Lectin H84T bound to dimannose
分子名称: GLYCEROL, Ripening-associated protein, alpha-D-mannopyranose, ...
著者Meagher, J.L, Stuckey, J.A.
登録日2014-05-09
公開日2015-11-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
4PIK
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BU of 4pik by Molmil
Crystal Structure of Banana Lectin bound to dimannose
分子名称: GLYCEROL, Ripening-associated protein, alpha-D-mannopyranose, ...
著者Meagher, J.L, Stuckey, J.A.
登録日2014-05-08
公開日2015-11-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
4PIF
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BU of 4pif by Molmil
Crystal Structure of recombinant WT Banana Lectin
分子名称: GLYCEROL, Ripening-associated protein
著者Meagher, J.L, Stuckey, J.A.
登録日2014-05-08
公開日2015-11-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
4PIU
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BU of 4piu by Molmil
CRYSTAL STRUCTURE OF BANANA LECTIN H84T MUTANT
分子名称: GLYCEROL, Ripening-associated protein, SODIUM ION
著者Meagher, J.L, Stuckey, J.A.
登録日2014-05-09
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity.
Cell, 163, 2015
6DL2
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BU of 6dl2 by Molmil
BRD4 bromodomain 1 in complex with HYB157
分子名称: 1,2-ETHANEDIOL, 3-benzyl-2,9-dimethyl-4H,6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepine, Bromodomain-containing protein 4
著者Meagher, J.L, Stuckey, J.A.
登録日2018-05-31
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
J. Med. Chem., 61, 2018
7TVA
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BU of 7tva by Molmil
Stat5a Core in complex with AK2292
分子名称: DI(HYDROXYETHYL)ETHER, MALONATE ION, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N-(5-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}pent-4-yn-1-yl)-N-methyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide, ...
著者Meagher, J.L, Stuckey, J.A.
登録日2022-02-04
公開日2023-02-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.835 Å)
主引用文献A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Nat.Chem.Biol., 19, 2023
7TVB
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BU of 7tvb by Molmil
Stat5A Core in Complex with AK305
分子名称: GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N,N-dimethyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide, Signal transducer and activator of transcription 5A
著者Meagher, J.L, Stuckey, J.A.
登録日2022-02-04
公開日2023-02-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.653 Å)
主引用文献A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Nat.Chem.Biol., 19, 2023
7UC6
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BU of 7uc6 by Molmil
Stat5a Core in complex with Compound 12
分子名称: N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(4-bromophenyl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A
著者Meagher, J.L, Stuckey, J.A.
登録日2022-03-16
公開日2023-02-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023
7UBT
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BU of 7ubt by Molmil
Stat5a Core in complex with Compound 18
分子名称: GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1,3-benzothiazol-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A
著者Meagher, J.L, Stuckey, J.A.
登録日2022-03-15
公開日2023-02-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023
7UC7
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BU of 7uc7 by Molmil
Stat5a Core in complex with Compound 17
分子名称: GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A
著者Meagher, J.L, Stuckey, J.A.
登録日2022-03-16
公開日2023-02-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.102 Å)
主引用文献Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023
4YOE
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BU of 4yoe by Molmil
Structure of UP1 bound to RNA 5'-AGU-3'
分子名称: ACETATE ION, Heterogeneous nuclear ribonucleoprotein A1, RNA AGU, ...
著者Meagher, J.L, Stuckey, J.A.
登録日2015-03-11
公開日2015-06-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein.
J.Mol.Biol., 427, 2015

 

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