2VSL

Crystal Structure of XIAP BIR3 with a Bivalent Smac Mimetic

Summary for 2VSL

• Entry DOI: 10.2210/pdb2vsl/pdb
• Related: 1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2JK7
• Descriptor: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, PEPTIDE (MAA-LYS-PRO-PHE), POLYETHYLENE GLYCOL (N=34), ... (5 entities in total)
• Functional Keywords: zinc-finger, polymorphism, smac mimetic, metal-binding, ubl conjugation pathway, thiol protease inhibitor, phosphoprotein, ubl conjugation, protease inhibitor, bir3, zinc, xiap, ligase, apoptosis, cytoplasm, hydrolase inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 2
• Total formula weight: 13161.22

Authors

Meagher, J.L.,Stuckey, J.A. (deposition date: 2008-04-24, release date: 2008-09-02, Last modification date: 2016-12-28)

• Primary citation: Nikolovska-Coleska, Z.,Meagher, J.L.,Jiang, S.,Yang, C.Y.,Qiu, S.,Roller, P.P.,Stuckey, J.A.,Wang, S.; Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein.; Biochemistry, 47:9811-, 2008; PubMed: 18717598; DOI: 10.1021/BI800785Y

Experimental method

X-RAY DIFFRACTION (2.1 Å)